Property Summary

NCBI Gene PubMed Count 65
PubMed Score 201.54
PubTator Score 389.71

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
psoriasis 6685 4.41402955592551E-16
pituitary cancer 1972 5.86401087774884E-14
pilocytic astrocytoma 3086 1.21447769964454E-11
ovarian cancer 8492 5.60981164456334E-8
posterior fossa group B ependymoma 1530 1.83231182560348E-7
pediatric high grade glioma 2712 1.49546398743678E-6
glioblastoma 5572 1.6134193521262E-6
tuberculosis 1563 1.80279705403496E-6
osteosarcoma 7933 4.23669958166903E-6
interstitial cystitis 2299 6.08938930349751E-5
lung cancer 4473 8.81495516877957E-5
head and neck cancer and chronic obstructive pulmonary disease 237 5.66736782921025E-4
Down syndrome 548 0.00124678053372961
colon cancer 1475 0.00316536710285618
invasive ductal carcinoma 2950 0.00677554713251204
active ulcerative colitis 477 0.0105285648513523
group 3 medulloblastoma 2254 0.0198205683257048
astrocytoma 1493 0.0248484474305849
medulloblastoma, large-cell 6234 0.0262234701028192
atypical teratoid / rhabdoid tumor 4369 0.0268016949209655
subependymal giant cell astrocytoma 2287 0.0337862249226907
Breast cancer 3099 0.0416881492106544
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0423848289201713
oligodendroglioma 2849 0.0439221370867514
Disease Target Count
Multiple synostoses syndrome 3 1


  Differential Expression (24)

Disease log2 FC p
astrocytoma -1.700 0.025
oligodendroglioma -1.100 0.044
psoriasis -1.400 0.000
glioblastoma -3.100 0.000
osteosarcoma -1.474 0.000
posterior fossa group B ependymoma -2.400 0.000
atypical teratoid / rhabdoid tumor -1.700 0.027
medulloblastoma, large-cell -2.400 0.026
active ulcerative colitis -1.653 0.011
tuberculosis -1.600 0.000
intraductal papillary-mucinous neoplasm ... 1.100 0.042
colon cancer -2.000 0.003
lung cancer 1.900 0.000
interstitial cystitis -3.500 0.000
pediatric high grade glioma -2.600 0.000
group 3 medulloblastoma -1.500 0.020
pilocytic astrocytoma -3.400 0.000
subependymal giant cell astrocytoma -2.343 0.034
Breast cancer -1.300 0.042
invasive ductal carcinoma -1.100 0.007
ovarian cancer -4.000 0.000
pituitary cancer -4.600 0.000
Down syndrome -1.300 0.001
head and neck cancer and chronic obstruc... -1.200 0.001


Accession P31371 A8K427 Q3SY32 FGF-9
Symbols GAF


PANTHER Protein Class (2)


1G82   1IHK  

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Pig OMA Inparanoid
Opossum OMA Inparanoid
Platypus OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (36)

26351673 the relative levels of FGF9 in relation to other members of the FGF family may prove key to understanding vulnerability or resilience in affective disorders.
26183774 Data indicate that expressing either human FGF9 in the kidney subcapsular space of female BALB/c mice yielded rapidly expanding local tumors.
25978641 These studies identify FGF9 as a target of DICER1 in lung epithelium that functions as an initiating factor for pleuropulmonary blastoma.
25925261 FGF9 was strongly expressed in CAFs in comparison with NGFs, being compatible with microarray data indicating that FGF9 was a novel growth factor overexpressed in Cancer-associated fibroblasts
25907862 our data demonstrate that FGF9 can initiate a complex astrocytic response predicted to compromise remyelination, while at the same time stimulating microglial/macrophage recruitment in multiple sclerosis lesions
25766327 we found that Kl treatment impairs Nodal mRNA expression and Fgf9-mediated Nanos2 induction, reinforcing the antagonistic effect of these two growth factors on the meiotic fate of male germ cells
24511001 FGF9 can be associated with epithelial-to-mesenchymal transition and invasion by inducing VEGF-A expression in prostate cancer cells.
24334956 The data demonstrates that FGF9 IRES functions as a cellular switch to turn FGF9 protein synthesis 'on' during hypoxia, a likely mechanism underlying FGF9 overexpression in cancer cells.
24239165 expression is associated with poor prognosis in lung cancer
24135036 MAP3K1 mutations tilt the balance in the sex-determining pathways by downregulating SOX9 and FGF9.

AA Sequence


Text Mined References (66)

PMID Year Title
26351673 2015 Fibroblast growth factor 9 is a novel modulator of negative affect.
26183774 2015 Fibroblast Growth Factor 9 Imparts Hierarchy and Vasoreactivity to the Microcirculation of Renal Tumors and Suppresses Metastases.
25978641 2015 Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma.
25925261 2015 FGF9 from cancer-associated fibroblasts is a possible mediator of invasion and anti-apoptosis of gastric cancer cells.
25907862 2015 Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9.
25766327 2015 Fgf9 inhibition of meiotic differentiation in spermatogonia is mediated by Erk-dependent activation of Nodal-Smad2/3 signaling and is antagonized by Kit Ligand.
24529757 2014 Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
24511001 2014 Accumulation of FGF9 in prostate cancer correlates with epithelial-to-mesenchymal transition and induction of VEGF-A expression.
24334956 2014 Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation.
24239165 2014 Expression of fibroblast growth factor 9 is associated with poor prognosis in patients with resected non-small cell lung cancer.