RRM2
Ribonucleoside-diphosphate reductase subunit M2
Protein Summary
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
- ENST00000304567
- ENSP00000302955
- ENSG00000171848
- ENST00000360566
- ENSP00000353770
- ENST00000615152
- ENSP00000484183
- ENST00000641198
- ENSP00000493399
- RR2
- R2
- RR2
- RR2M
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein complex | 0.96 | ||
transcription factor perturbation | 0.96 | ||
gene perturbation | 0.93 | ||
transcription factor binding site profile | 0.85 | ||
microRNA | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1274.38 (req: < 5)
Gene RIFs: 127 (req: <= 3)
Antibodies: 270 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1274.38 (req: >= 5)
Gene RIFs: 127 (req: > 3)
Antibodies: 270 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3