Tclin HTR1F 5-hydroxytryptamine receptor 1F

Protein Summary

Description

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Uniprot Accession IDs

• P30939
• 5-HT-1F

Gene Name

• HTR1F

Ensembl ID

• ENST00000319595
• ENSP00000322924
• ENSG00000179097

Symbol

• HTR1EL
• 5HT6
• MR77
• 5-HT1F
• HTR1EL
• 5-HT-1F

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.97
microRNA	0.65
molecular function	0.63
drug	0.6
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / 5-hydroxytryptamine Receptor 1f

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / 5-hydroxytryptamine Receptor / 5-ht1 Receptor / 5-hydroxytryptamine Receptor 1f

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.1   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 197   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.1   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 111

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14