Tclin SSTR1 Somatostatin receptor type 1

Protein Summary

Description

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• P30872
• SS-1-R

Gene Name

• SSTR1

Ensembl ID

• ENST00000267377
• ENSP00000267377
• ENSG00000139874

Symbol

• SS1R
• SS1-R
• SRIF-2
• SS-1-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.84
ligand (chemical)	0.8
cell type or tissue	0.61
PubMedID	0.6
biological process	0.59

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Somatostatin Receptor Type 1

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Somatostatin Receptor Type 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.87   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 400   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 162.87   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 67

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3