Tclin AGTR1 Type-1 angiotensin II receptor

Protein Summary

Description

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• P30556
• Q13725
• Q8TBK4

Gene Name

• AGTR1

Ensembl ID

• ENST00000349243
• ENSP00000273430
• ENSG00000144891
• ENST00000404754
• ENSP00000385612
• ENST00000461609
• ENSP00000418851
• ENST00000474935
• ENSP00000418084
• ENST00000475347
• ENSP00000419783
• ENST00000497524
• ENSP00000419422

Symbol

• AGTR1A
• AGTR1B
• AT2R1
• AT2R1B
• AT1
• AG2S
• AT1B
• AT1R
• AT1AR
• AT1BR
• AT2R1
• HAT1R
• AGTR1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.94
biological process	0.91
biological term	0.86
disease	0.85
disease perturbation	0.74

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Angiotensin Receptor / Type-1 Angiotensin Ii Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3422.67   (req: < 5)

Gene RIFs: 668   (req: <= 3)

Antibodies: 457   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3422.67   (req: >= 5)

Gene RIFs: 668   (req: > 3)

Antibodies: 457   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 621

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12