Tchem P30536 Translocator protein

Protein Summary

Description

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678). Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• P30536
• Q53Y59
• Q6ICF9
• Q96TF6

Gene Name

• TSPO

Ensembl ID

• ENST00000329563
• ENSP00000328973
• ENSG00000100300
• ENST00000337554
• ENSP00000338004
• ENST00000396265
• ENSP00000379563

Symbol

• BZRP
• MBR
• DBI
• IBP
• MBR
• PBR
• PBS
• BPBS
• BZRP
• PKBS
• PTBR
• mDRC
• pk18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease perturbation	1
cellular component	0.97
transcription factor perturbation	0.91
kinase perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3413.34   (req: < 5)

Gene RIFs: 170   (req: <= 3)

Antibodies: 248   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3413.34   (req: >= 5)

Gene RIFs: 170   (req: > 3)

Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 97

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1