Tchem ADSS Adenylosuccinate synthetase isozyme 2

Protein Summary

Description

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• P30520
• B1AQM5
• Q96EG7
• AMPSase 2

Gene Name

• ADSS

Ensembl ID

• ENST00000366535
• ENSP00000355493
• ENSG00000035687

Symbol

• ADSS2
• ADEH
• ADSS 2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
disease perturbation	0.87
transcription factor binding site profile	0.85
biological process	0.69
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Ligase / Adenylosuccinate Synthetase Isozyme 2

DTO Classes

Protein / Enzyme / Ligase / Adenylosuccinate Synthetase Isozyme 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.77   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.77   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0