Tclin AVPR2 Vasopressin V2 receptor

Protein Summary

Description

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P30518
• C5HF20
• O43192
• Q3MJD3
• Q9UCV9
• V2R

Gene Name

• AVPR2

Ensembl ID

• ENST00000337474
• ENSP00000338072
• ENSG00000126895
• ENST00000358927
• ENSP00000351805
• ENST00000370049
• ENSP00000359066
• ENST00000646375
• ENSP00000496396

Symbol

• ADHR
• DIR
• DIR3
• V2R
• DI1
• DIR
• NDI
• V2R
• ADHR
• DIR3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	1
biological process	0.91
tissue	0.63
biological term	0.6
cellular component	0.6

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Vasopressin V2 Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Vasopressin V2 Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1461.74   (req: < 5)

Gene RIFs: 103   (req: <= 3)

Antibodies: 262   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1461.74   (req: >= 5)

Gene RIFs: 103   (req: > 3)

Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 420

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6