Property Summary

NCBI Gene PubMed Count 54
PubMed Score 67.36
PubTator Score 55.03

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Multiple Sclerosis 498
Disease Target Count P-value
lung carcinoma 2844 1.38609735362736E-21
juvenile dermatomyositis 1189 2.38147093331119E-16
pilocytic astrocytoma 3086 9.71140225772366E-11
posterior fossa group A ependymoma 1511 2.47174618489364E-7
lung cancer 4473 8.249559362053E-6
ovarian cancer 8492 1.5507716585963E-4
glioblastoma 5572 1.87405489939261E-4
pancreatic cancer 2300 5.04485989983829E-4
osteosarcoma 7933 6.34962914355717E-4
pediatric high grade glioma 2712 0.001257414855211
invasive ductal carcinoma 2950 0.00131249074229028
interstitial cystitis 2299 0.00409049893075754
limb girdle muscular dystrophy 2I 56 0.00428760708638332
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00493021044566005
active Crohn's disease 918 0.00617383917221125
cutaneous lupus erythematosus 1056 0.00754276885105267
subependymal giant cell astrocytoma 2287 0.0104882643129646
active ulcerative colitis 477 0.0117461664684255
dermatomyositis 967 0.014017943752555
esophageal adenocarcinoma 737 0.0176010007179145
primary Sjogren syndrome 789 0.0186775275183482
astrocytoma 1493 0.0258927471879525
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0294331217210313
Multiple myeloma 1328 0.034773495964583
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0409685951032001
Disease Target Count Z-score Confidence
Hemochromatosis 55 4.518 2.3
Juvenile myoclonic epilepsy 17 3.101 1.6



Accession P30511 Q5JQI8 Q5JQJ1 Q5SPT5 Q860R0 Q8MGQ1 Q8WLP5 Q95HC0 Q9TP68
Symbols HLAF


  Ortholog (3)

Species Source
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid

Gene RIF (92)

26928464 Overexpression of a single MHCI molecule, HLA-F, protects human MNs from ALS astrocyte-mediated toxicity, whereas knockdown of its receptor, the killer cell immunoglobulin-like receptor KIR3DL2, on human astrocytes results in enhanced motor neurons death
26332651 provides substantial evidence that the rs7903146 variant is significantly associated with the risk of diabetic retinopathy in Caucasian populations
25862890 We identified that the HLA-E and HLA-F in gastric cancer independently affected clinical factors, including postoperative outcome
25461528 The effect of Japanese encephalitis virus and TNF-alpha exposure on NFkappaB-mediated induction of HLA-F is reported.
25420801 Review of the impact of human leukocyte antigen molecules E, F, and G on the outcome of transplantation.
25413105 This is the first study regarding HLA-F polymorphisms in a Euro-Brazilian population contributing to the Southern Brazilian genetic characterization.
24018270 HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.
23851683 A previously unrecognized model of Ag cross-presentation mediated by HLA-F & MHC-I open conformers on activated lymphocytes & monocytes may significantly contribute to the regulation of immune system functions & the immune defense.
23542057 expression in gastric cancer lesion was unrelated to patient prognosis
22980333 HIV-1 Nef downregulates the expression of MHC-I at the surface of lymphoid, monocytic and epithelial cells, causing MHC-I molecules to be rapidly internalized, accumulated in endosomal vesicles and degraded

AA Sequence


Text Mined References (55)

PMID Year Title
26928464 2016 Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis.
26332651 2015 Clinical implication of human leukocyte antigen (HLA)-F expression in breast cancer.
25862890 2015 Human leukocyte antigen (HLA)-E and HLA-F expression in gastric cancer.
25461528 2014 Infection of human amniotic and endothelial cells by Japanese encephalitis virus: Increased expression of HLA-F.
25420801 2014 Impact of human leukocyte antigen molecules E, F, and G on the outcome of transplantation.
25413105 2014 HLA-F polymorphisms in a Euro-Brazilian population from Southern Brazil.
24018270 2013 HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.
23851683 2013 HLA-F and MHC-I open conformers cooperate in a MHC-I antigen cross-presentation pathway.
23542057 2013 Lesion HLA-F expression is irrelevant to prognosis for patients with gastric cancer.
22544725 2013 Alteration of HLA-F and HLA I antigen expression in the tumor is associated with survival in patients with esophageal squamous cell carcinoma.