Tbio HLA-F HLA class I histocompatibility antigen, alpha chain F

Protein Summary

Description

Involved in the presentation of foreign antigens to the immune system. This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P30511
• Q5JQI8
• Q5JQJ1
• Q5SPT5
• Q860R0
• Q8MGQ1
• Q8WLP5
• Q95HC0
• Q9TP68

Gene Name

• HLA-F

Ensembl ID

• ENST00000259951
• ENSP00000259951
• ENSG00000204642
• ENST00000334668
• ENSP00000334263
• ENST00000359076
• ENSP00000351977
• ENSG00000206509
• ENST00000376848
• ENSP00000366044
• ENSG00000229698
• ENST00000376861
• ENSP00000366057
• ENST00000383515
• ENSP00000373007
• ENSG00000137403
• ENST00000420067
• ENSP00000393535
• ENSG00000235220
• ENST00000434407
• ENSP00000397376
• ENST00000440590
• ENSP00000399835
• ENSG00000237508

Symbol

• HLA-5.4
• HLAF
• HLAF
• CDA12
• HLA-5.4
• HLA-CDA12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
protein domain	0.97
PubMedID	0.94
disease perturbation	0.79
phenotype	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.44   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 149   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.44   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0