Property Summary

NCBI Gene PubMed Count 1,181
PubMed Score 4042.73
PubTator Score 2865.77

Knowledge Summary


No data available


  Disease Sources (5)

Disease Target Count P-value
juvenile dermatomyositis 1189 1.23577221105006E-17
pilocytic astrocytoma 3086 3.73904744119135E-10
posterior fossa group A ependymoma 1511 2.06436030018893E-9
Duchenne muscular dystrophy 602 5.97678268819902E-7
ovarian cancer 8492 1.26743510048199E-6
glioblastoma 5572 6.08956977337242E-5
lung cancer 4473 9.65328174781685E-5
cutaneous lupus erythematosus 1056 3.06769341689203E-4
adult high grade glioma 2148 5.26533614347567E-4
dermatomyositis 967 0.00388402017729801
subependymal giant cell astrocytoma 2287 0.00702279895562658
astrocytoma 1493 0.0103627276976911
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0114551174281074
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0117844625080605
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0229548872117084
inflammatory breast cancer 404 0.0279408836536346
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0319695823777265
Disease Target Count Z-score Confidence
Juvenile rheumatoid arthritis 105 0.0 5.0
Disease Target Count
Birdshot chorioretinopathy 23


  Ortholog (2)

Species Source
Macaque OMA EggNOG

Gene RIF (1205)

26974162 Promiscuous Recognition of a Trypanosoma cruzi CD8+ T Cell Epitope among HLA-A2, HLA-A24 and HLA-A1 Supertypes in Chagasic Patients.
26967484 HLA-A alleles are associated with dermatitis herpetiformis in Chinese population.
26787886 Vitiligo risk associated with the MHC class I region thus derives from combined quantitative and qualitative phenomena: a SNP haplotype in a transcriptional regulator that induces gain-of-function, elevating expression of HLA-A RNA
26656886 the carriage of HLA-A SNP rs1655900 studied is not associated with the susceptibility to CT infection based on the data from the STD cohort.
26621839 Data indicate that adoptive transfer of peptide-induced cytotoxic T lymphocytes (CTL) cells from HLA-A2 transgenic mice into human tumor xenograft SCID mice significantly inhibited tumor growth.
26600404 This report presents results of a study of similarities and dissimilarities comparing all possible pairs of 43 high resolution X-ray structures of human HLA-A2.
26564811 expression on melanoma variants with B-Raf kinase inhibitors plays a major role in their susceptibility to NK-cell cytotoxicity
26507656 mutant N-terminally extended peptides exhibited significantly increased HLA-A*02:01 binding affinity and elicited CD8(+) T cell stimulation in vitro similar to the wtgp100209-217 epitope.
26490229 HLA-A*31:01 was confirmed to be significantly associated with definite/probable cases of Stevens-Johnson syndrome/toxic epidermal necrolysis
26448174 HLA-A*02:06 with Toll Like Receptor 3 polymorphisms and HLA-A*02:06 with prostaglandin e receptor-3 polymorphisms exerted additive effects in Stevens-Johnson Syndrome with Surface Ocular Complications

AA Sequence

DSAQGSDMSLTACKV                                                           351 - 365

Text Mined References (1185)

PMID Year Title
26974162 2016 Promiscuous Recognition of a Trypanosoma cruzi CD8+ T Cell Epitope among HLA-A2, HLA-A24 and HLA-A1 Supertypes in Chagasic Patients.
26967484 2016 The HLA Alleles B*0801 and DRB1*0301 Are Associated with Dermatitis Herpetiformis in a Chinese Population.
26787886 2016 Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo.
26656886 2016 Potential protective effect of a G>A SNP in the 3'UTR of HLA-A for Chlamydia trachomatis symptomatology and severity of infection.
26621839 2016 A HLA-A2-restricted CTL epitope induces anti-tumor effects against human lung cancer in mouse xenograft model.
26600404 2016 Clusters of Structurally Similar MHC I HLA-A2 Molecules, Found with a New Method, Suggest Mechanisms of T-Cell Receptor Avidity.
26564811 2016 HLA class I downregulation is associated with enhanced NK-cell killing of melanoma cells with acquired drug resistance to BRAF inhibitors.
26507656 2015 The T210M Substitution in the HLA-a*02:01 gp100 Epitope Strongly Affects Overall Proteasomal Cleavage Site Usage and Antigen Processing.
26490229 2015 Development of a simple genotyping method for the HLA-A*31:01-tagging SNP in Japanese.
26448174 2015 Genetic Predisposition to Stevens-Johnson Syndrome With Severe Ocular Surface Complications.