| Tclin | B2 bradykinin receptor |
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 310 |
| NCBI Gene PubMed Count | 199 |
| PubMed Score | 0.00 |
| PubTator Score | 346.38 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hypertension | 396 | 3.394 | 1.7 |
| Acute kidney injury | 70 | 0.0 | 0.0 |
| Arthritis, Rheumatoid | 174 | 0.0 | 0.0 |
| Cardiomyopathies | 110 | 0.0 | 0.0 |
| Epilepsy, Temporal Lobe | 23 | 0.0 | 0.0 |
| Extravasation of Diagnostic and Therapeutic Materials | 6 | 0.0 | 0.0 |
| Hemorrhage | 19 | 0.0 | 0.0 |
| Hyperalgesia | 83 | 0.0 | 0.0 |
| Hyperemia | 13 | 0.0 | 0.0 |
| Hypotension | 82 | 0.0 | 0.0 |
| Inflammation | 120 | 0.0 | 0.0 |
| Pain | 103 | 0.0 | 0.0 |
| Thrombosis | 46 | 0.0 | 0.0 |
| Vascular System Injuries | 9 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Bipolar Disorder | 666 |
| Hypertensive disease | 292 |
| Major Depressive Disorder | 301 |
| Rheumatoid arthritis | 1191 |
| Unipolar Depression | 250 |
| Disease | Target Count |
|---|---|
| Hereditary angioneurotic edema | 4 |
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3232 | 8.7e-10 |
| lung adenocarcinoma | 2716 | 3.4e-05 |
| cystic fibrosis | 1696 | 1.1e-04 |
| lung cancer | 4740 | 4.4e-04 |
| group 4 medulloblastoma | 1855 | 1.7e-03 |
| invasive ductal carcinoma | 2951 | 3.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Angioedema | 38 | 4.226 | 2.1 |
| RETINITIS PIGMENTOSA 68 | 2 | 3.877 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| cystic fibrosis | 3.435 | 1.1e-04 |
| group 4 medulloblastoma | -1.100 | 1.7e-03 |
| invasive ductal carcinoma | -1.299 | 3.2e-02 |
| lung adenocarcinoma | 1.500 | 3.4e-05 |
| lung cancer | -1.400 | 4.4e-04 |
| malignant mesothelioma | -4.700 | 8.7e-10 |
CHEMBL209130
pKi 7.00
CHEMBL207465
pKi 7.00
CHEMBL267822
pKi 7.00
CHEMBL3215541
pIC50 7.01
CHEMBL1907652
pKi 7.02
CHEMBL295005
pIC50 7.03
CHEMBL27702
pKi 7.04
CHEMBL561899
pIC50 7.05
CHEMBL3215529
pIC50 7.06
CHEMBL3350763
pKi 7.07
CHEMBL295428
pIC50 7.10
CHEMBL550143
pIC50 7.10
CHEMBL210100
pKi 7.10
CHEMBL380206
pKi 7.10
CHEMBL159066
pKi 7.10
CHEMBL542911
pIC50 7.11
CHEMBL26192
pKi 7.12
CHEMBL26847
pKi 7.13
CHEMBL130660
pIC50 7.13
CHEMBL286556
pKi 7.14
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVL 1 - 70 ATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMN 71 - 140 LYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTA 141 - 210 CVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFI 211 - 280 ICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGV 281 - 350 CQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ 351 - 391 //
