Property Summary

NCBI Gene PubMed Count 47
PubMed Score 88.63
PubTator Score 103.68

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Drug allergy 36
Disease Target Count P-value
lung carcinoma 2844 8.07663996446503E-32
non-small cell lung cancer 2798 7.09464179196679E-13
chronic lymphosyte leukemia 232 2.71563197923536E-9
lung cancer 4473 1.45907354699626E-6
pilocytic astrocytoma 3086 3.43208525423634E-6
ulcerative colitis 2087 5.25250589983364E-6
ovarian cancer 8492 6.72066695363763E-6
malignant mesothelioma 3163 1.29003200063585E-5
glioblastoma 5572 9.09582976822161E-5
psoriasis 6685 1.20046130814728E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 3.14393501900967E-4
invasive ductal carcinoma 2950 4.5064946007804E-4
posterior fossa group A ependymoma 1511 5.43756654189029E-4
cutaneous lupus erythematosus 1056 6.61375536862765E-4
interstitial cystitis 2299 9.83181488982706E-4
osteosarcoma 7933 0.00173070342233049
head and neck cancer and chronic obstructive pulmonary disease 237 0.00185527146897137
pediatric high grade glioma 2712 0.00330027152884905
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00411020948298578
medulloblastoma, large-cell 6234 0.00620963301992948
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00691225690472503
pancreatic cancer 2300 0.00878348023544376
mucosa-associated lymphoid tissue lymphoma 480 0.0114778135140591
adrenocortical carcinoma 1427 0.0151833577056238
Down syndrome 548 0.0190682468422288
group 3 medulloblastoma 2254 0.0253861393135438
subependymal giant cell astrocytoma 2287 0.0271177979195145
esophageal adenocarcinoma 737 0.0290080819161667
astrocytoma 1493 0.0384064825621469
Breast cancer 3099 0.0436840106081678
Disease Target Count Z-score Confidence
T lymphocyte deficiency 7 3.906 2.0



Accession P30273 Q5VTW4
Symbols FCRG


  Ortholog (7)

Gene RIF (28)

25513989 Data indicate that the decreasing trend in the expression level of TCRzeta chain, ZAP-70 kinase and epsilon Fc Receptors FcvarepsilonRIgamma was significantly associated with disease progression.
24023253 Studies indicate that in response to stimulation with antigen, PHB1 translocated to plasma membrane lipid rafts to form a ternary complex with the high-affinity IgE receptor FcepsilonRIgamma and the nonreceptor tyrosine kinase Syk.
23874603 A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) expression by HIV-1 Vpr in Vpr transduced macrophages
23228155 High expression of FCER1G is associated with chronic myeloid leukemia.
22706086 CD2-associated adaptor protein (CD2AP) positively regulates blood dendritic cell antigen 2 (BDCA2)/FcepsilonR1gamma signaling by forming a complex with SH2 domain-containing inositol 5'-phosphatase (SHIP)1 to inhibit the E3 ubiquitin ligase Cbl.
22664044 There was loss of the negative correlation in the expression levels of CD3eta and FcepsilonRIgamma genes in CLL patients.
22401598 Altered expression of the TCR signaling related genes CD3 and FcepsilonRIgamma in patients with aplastic anemia.
22150093 Demethylation of specific regulatory elements within the FCER1G locus contributes to FcepsilonRI overexpression on monocytes from patients with atopic dermatitis.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20438785 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

AA Sequence

RNQETYETLKHEKPPQ                                                           71 - 86

Text Mined References (52)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25513989 2015 Characteristics of TCR?, ZAP-70, and Fc?RI? gene expression in patients with T- and NK/T-cell lymphoma.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24023253 2013 A role for prohibitin in mast cell activation: location matters.
23228155 2012 Alternative expression of TCR? related genes in patients with chronic myeloid leukemia.
22706086 2012 CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl.
22664044 2012 Expression feature of CD3, Fc?RI?, and Zap-70 in patients with chronic lymphocytic leukemia.
22401598 2012 Altered expression of the TCR signaling related genes CD3 and Fc?RI? in patients with aplastic anemia.
22150093 2012 Demethylation of the FCER1G promoter leads to Fc?RI overexpression on monocytes of patients with atopic dermatitis.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.