Property Summary

NCBI Gene PubMed Count 19
Grant Count 15
R01 Count 15
Funding $1,605,583.5
PubMed Score 51.77
PubTator Score 15.35

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (11)

Disease log2 FC p
nephrosclerosis -1.747 0.010
esophageal adenocarcinoma -1.500 0.018
osteosarcoma -1.041 0.000
group 3 medulloblastoma -1.800 0.002
medulloblastoma, large-cell -1.300 0.009
primitive neuroectodermal tumor -1.100 0.029
Atopic dermatitis 1.400 0.000
pancreatic ductal adenocarcinoma liver m... -2.561 0.017
lung cancer 1.200 0.000
interstitial cystitis -2.900 0.000
psoriasis 1.200 0.000

Gene RIF (6)

PMID Text
22516612 the impact of the hyperprolinemia-associated mutation of Ser352 to Leu on the structure and catalytic properties of the P5CDH
20877624 Observational study of gene-disease association. (HuGE Navigator)
20453000 Observational study of gene-disease association. (HuGE Navigator)
19898482 Observational study of gene-disease association. (HuGE Navigator)
14986171 ALDH4 is a p53-inducible gene with a protective role in cellular stresses
14986171 ALDH4 is transcriptionally induced by p53.

AA Sequence

MLLPAPALRRALLSRPWTGAGLRWKHTSSLKVANEPVLAFTQGSPERDALQKALKDLKGRMEAIPCVVGD      1 - 70
EEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRR     71 - 140
AEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPF    141 - 210
NFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLC    211 - 280
GINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSA    281 - 350
CSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK    351 - 420
CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVV    421 - 490
QEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWSYA    491 - 560
YMQ                                                                       561 - 563
//

Text Mined References (26)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23825041 2013 A novel ALDH5A1 mutation is associated with succinic semialdehyde dehydrogenase deficiency and severe intellectual disability in an Iranian family.
23568457 2013 Genetic variants associated with disordered eating.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22516612 2012 The three-dimensional structural basis of type II hyperprolinemia.
21998747 2011 Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria.
21269460 2011 Initial characterization of the human central proteome.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
20453000 2010 A Large-scale genetic association study of esophageal adenocarcinoma risk.
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