Protein Summary
Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP. The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000309170
- ENSP00000308361
- ENSG00000174944
- ENST00000424796
- ENSP00000408733
- GPR105
- KIAA0001
- P2Y14
- BPR105
- GPR105
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.9 | ||
PubMedID | 0.67 | ||
microRNA | 0.6 | ||
cell type or tissue | 0.53 | ||
molecular function | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 88.54 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 223 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 88.54 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 223 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 48
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0