| Tchem | P2X purinoceptor 5 |
Receptor for ATP that acts as a ligand-gated ion channel.
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 1.3e-09 |
| Astrocytoma, Pilocytic | 3081 | 5.5e-08 |
| psoriasis | 6694 | 6.4e-08 |
| Chronic Lymphocytic Leukemia | 262 | 2.0e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 5.3e-07 |
| group 3 medulloblastoma | 4104 | 6.0e-06 |
| glioblastoma | 5792 | 9.5e-05 |
| primary Sjogren syndrome | 735 | 4.3e-04 |
| interstitial cystitis | 2312 | 1.3e-03 |
| astrocytic glioma | 2597 | 2.3e-03 |
| nasopharyngeal carcinoma | 1058 | 2.4e-03 |
| lung cancer | 4740 | 2.5e-03 |
| oligodendroglioma | 2850 | 2.9e-03 |
| ependymoma | 4679 | 2.9e-03 |
| ulcerative colitis | 1819 | 3.9e-03 |
| cutaneous lupus erythematosus | 1057 | 6.1e-03 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | -1.400 | 2.3e-03 |
| Astrocytoma, Pilocytic | -1.500 | 5.5e-08 |
| atypical teratoid / rhabdoid tumor | -1.500 | 5.3e-07 |
| Chronic Lymphocytic Leukemia | -2.229 | 2.0e-07 |
| cutaneous lupus erythematosus | 2.600 | 6.1e-03 |
| ependymoma | -1.600 | 2.9e-03 |
| glioblastoma | -1.200 | 9.5e-05 |
| group 3 medulloblastoma | -1.900 | 6.0e-06 |
| interstitial cystitis | 2.900 | 1.3e-03 |
| lung cancer | 1.600 | 2.5e-03 |
| nasopharyngeal carcinoma | -1.300 | 2.4e-03 |
| oligodendroglioma | -1.500 | 2.9e-03 |
| osteosarcoma | -4.705 | 1.3e-09 |
| primary Sjogren syndrome | 1.900 | 4.3e-04 |
| psoriasis | 1.100 | 6.4e-08 |
| ulcerative colitis | 1.700 | 3.9e-03 |
MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVITKV 1 - 70 KGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGACSKDSDCHAGEA 71 - 140 VTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMD 141 - 210 VKDRSFLKSCHFGPKNHYCPIFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSR 211 - 280 LDNKLSKSVSSGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKGAFFCDLVLIYLIKKREFYRDKK 281 - 350 YEEVRGLEDSSQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHR 351 - 420 ST 421 - 422 //
