Property Summary

NCBI Gene PubMed Count 267
PubMed Score 1040.51
PubTator Score 1078.46

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
non-small cell lung cancer 2798 2.2096467859074E-23
lung carcinoma 2844 3.34563439537988E-18
ovarian cancer 8492 3.02726023852887E-16
posterior fossa group A ependymoma 1511 2.06180364457403E-14
glioblastoma multiforme 347 8.41187987498667E-14
astrocytoma 1493 9.67876285589083E-10
intraductal papillary-mucinous adenoma (IPMA) 2956 1.11745678910588E-7
lung cancer 4473 3.23268464482791E-6
non-inflammatory breast cancer 208 3.26847215769799E-5
intraductal papillary-mucinous neoplasm (IPMN) 3289 3.76682014333986E-5
invasive ductal carcinoma 2950 6.99525596864288E-5
lung adenocarcinoma 2714 7.74127806619966E-5
pterygium 74 1.46160555972719E-4
breast carcinoma 1614 1.88768308631993E-4
interstitial cystitis 2299 2.19041512129353E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 4.51000004867852E-4
psoriasis 6685 9.72107160237205E-4
Down syndrome 548 0.00130224059058921
ductal carcinoma in situ 1745 0.00233158777740118
adult high grade glioma 2148 0.00363861289586016
subependymal giant cell astrocytoma 2287 0.0039307077422542
urothelial carcinoma 318 0.00432826055561684
pancreatic cancer 2300 0.00628105251412145
mucosa-associated lymphoid tissue lymphoma 480 0.0126560750497382
pilocytic astrocytoma 3086 0.0233450762984572
gastric carcinoma 832 0.0258166083592486
osteosarcoma 7933 0.0279019468702375
primary pancreatic ductal adenocarcinoma 1271 0.0348405091628658



Accession P29972 B5BU39 E7EM69 E9PC21 F5GY19 Q8TBI5 Q8TDC1 AQP-1
Symbols CO


PANTHER Protein Class (1)


1FQY   1H6I   1IH5   4CSK  

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Chicken OMA EggNOG
Anole lizard OMA EggNOG

Gene RIF (168)

27295912 Urinary AQP1 is significantly lower in patients with clear cell renal carcinoma than in controls. Urinary AQP1 increases after nephrectomy in clear cell renal carcinoma patients.
26823734 Suggest that sputum AQP1 and AQP5 could be used as diagnostic markers in mild-to-moderate adult-onset asthma.
26786101 Based on a comparative mutagenic analysis of AQP1, AQP 3, and AQP 4, the results suggest that loop D interactions may provide a general structural framework for tetrameric assembly within the AQP family.
26773069 The role of AQP1 in malignant pleural mesothelioma.
26717516 These data provide support for a continuous role of KLF2 in stabilizing the vessel wall via co-temporal expression of eNOS and AQP1 both preceding and during the pathogenesis of atherosclerosis.
26549133 the downregulation of AQP1 impedes extracellular to intracellular fluid transportation.
26261083 The study demonstrated the abnormal expression pattern of AQP1, AQP2, AQP3, and AQP4 in the kidney tissues of patients with nephrotic syndrome, providing a basis for an improved understanding of the role of aquaporins in the pathogenesis of this disease.
26181025 Results demonstrate the clinical utility, specificity, and sensitivity of urine AQP1 and PLIN2 to diagnose renal cell carcinoma.
26178576 PBEF regulates the expression of inflammatory factors and AQP1 through the MAPK pathways.
26176849 AQP1 knockdown can effectively inhibit cell proliferation, adhesion, invasion and tumorigenesis by targeting TGF-beta signaling pathway and focal adhesion genes.

AA Sequence


Text Mined References (269)

PMID Year Title
27295912 2016 Urinary KIM-1 and AQP-1 in patients with clear renal cell carcinoma: Potential noninvasive biomarkers.
26823734 2015 Use of aquaporins 1 and 5 levels as a diagnostic marker in mild-to-moderate adult-onset asthma.
26786101 2016 Structural Determinants of Oligomerization of the Aquaporin-4 Channel.
26773069 2016 Influence of AQP1 on cell adhesion, migration, and tumor sphere formation in malignant pleural mesothelioma is substratum- and histological-type dependent.
26717516 2015 Expression of Nitric Oxide-Transporting Aquaporin-1 Is Controlled by KLF2 and Marks Non-Activated Endothelium In Vivo.
26549133 2016 Inhibition of the expression of aquaporin?1 by RNA interference in pulmonary epithelial cells and its effects on water transport.
26261083 2015 Expression pattern of aquaporins in patients with primary nephrotic syndrome with edema.
26181025 2015 Evaluation of Urine Aquaporin-1 and Perilipin-2 Concentrations as Biomarkers to Screen for Renal Cell Carcinoma: A Prospective Cohort Study.
26178576 2015 PBEF promotes the apoptosis of pulmonary microvascular endothelial cells and regulates the expression of inflammatory factors and AQP1 through the MAPK pathways.
26176849 2015 RNAi-mediated silencing of AQP1 expression inhibited the proliferation, invasion and tumorigenesis of osteosarcoma cells.