Property Summary

NCBI Gene PubMed Count 50
PubMed Score 52.62
PubTator Score 34.42

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (4)

Disease Target Count
Intellectual disability 573
Disease Target Count P-value
ependymoma 2514 9.41749277691615E-10
ovarian cancer 8492 2.84842687068005E-7
Pick disease 1893 3.83799860053365E-7
osteosarcoma 7933 9.83119677101036E-7
medulloblastoma 1524 2.76321649530145E-6
atypical teratoid / rhabdoid tumor 4369 4.55502194689325E-6
primitive neuroectodermal tumor 3031 8.61127233707756E-5
psoriasis 6685 8.92464460390109E-5
glioblastoma 5572 1.12686359725089E-4
tuberculosis and treatment for 6 months 686 1.22458099249717E-4
medulloblastoma, large-cell 6234 2.41697533577544E-4
hepatocellular carcinoma 550 4.03716701531147E-4
pediatric high grade glioma 2712 4.62307121340027E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 8.57383382712559E-4
dermatomyositis 967 0.00125364191165388
astrocytoma 1493 0.00161589224235856
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0016232601672106
ulcerative colitis 2087 0.00495358047948317
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0185252449532747
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0207287517244379
Rheumatoid Arthritis 1171 0.0219958965406869
Alzheimer's disease 644 0.0235841607302653
Breast cancer 3099 0.0465152711029208
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Cancer 2346 3.251 1.6
Advanced sleep phase syndrome 10 3.05 1.5

Expression

Synonym

Accession P29375 A8MV76 Q4LE72 Q86XZ1
Symbols RBP2
RBBP2
RBBP-2

Gene

PDB

5C11   2JXJ   2KGG   2KGI   3GL6   5CEH   5E6H   5ISL   5IVB   5IVC   5IVE   5IVF   5IVJ   5IVV   5IVY   5IW0   5IWF   5K4L  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid

Gene RIF (29)

PMID Text
26645689 Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.
26566863 Treatment-induced temozolimide resistance in glioblastoma cells involves KDM5A mediated epigenetic mechanisms.
25686748 KDM5A is regulated by its reader domain through a positive-feedback mechanism
25575817 Data indicate that lysine (K)-specific demethylase 5A RBP2 (JARID1A; KDM5A) epigenetically downregulated micrRNA-21 (miR-21) in blast transformation of chronic myeloid leukemia (CML).
25190814 KDM5A and the NuRD complex cooperatively function to control developmentally regulated genes
25015565 RBP2 may link chronic inflammation to tumor development.
24716659 Overexpression of RBP2 and activation of VEGF might play important roles in human gastric cancer development and progression.
24582965 RBP2 is critical for breast cancer metastasis to the lung in multiple in vivo models. Mechanistically, RBP2 promotes metastasis as a pleiotropic positive regulator of many metastasis genes, including TNC.
24442343 Epigenetic changes mediated by JARID1A, SMYD3 and DNA methylation may be responsible, at least in part, for the functional progesterone withdrawal that precipitates human labour.
24376841 RBP2 down-regulated the expression of E-cadherin, up-regulated the expression of N-cadherin and snail, and induced epithelial-mesenchymal transition in non-small cell lung cancer cells.
More...

AA Sequence

MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRF      1 - 70
TPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWS     71 - 140
KVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPNLDLKEKVEPEVLSTDTQTSPEPGTR    141 - 210
MNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMR    211 - 280
QRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPRE    281 - 350
AFGFEQAVREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGS    351 - 420
GFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSY    421 - 490
SINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAG    491 - 560
EFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVG    561 - 630
LAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCL    631 - 700
YHPTDLCPCPMQKKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDA    701 - 770
EDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFSLPCVI    771 - 840
SQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQARWLDEVRLT    841 - 910
LSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSVASLESIVNE    911 - 980
AKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAKGRPIPVRLEALPQVESQVAAA    981 - 1050
RAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEET   1051 - 1120
RDTAMVVAVFKEREQKEIEAMHSLRAANLAKMTMVDRIEEVKFCICRKTASGFMLQCELCKDWFHNSCVP   1121 - 1190
LPKSSSQKKGSSWQAKEVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRA   1191 - 1260
RQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSS   1261 - 1330
SPRQTMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEH   1331 - 1400
AYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQ   1401 - 1470
ATHPPSEDRFLHIMEDDSMEEKPLKVKGKDSSEKKRKRKLEKVEQLFGEGKQKSKELKKMDKPRKKKLKL   1471 - 1540
GADKSKELNKLAKKLAKEEERKKKKEKAAAAKVELVKESTEKKREKKVLDIPSKYDWSGAEESDDENAVC   1541 - 1610
AAQNCQRPCKDKVDWVQCDGGCDEWFHQVCVGVSPEMAENEDYICINCAKKQGPVSPGPAPPPSFIMSYK   1611 - 1680
LPMEDLKETS                                                               1681 - 1690
//

Text Mined References (61)

PMID Year Title
26645689 2016 Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.
26566863 2015 The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.
25686748 2015 Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism.
25575817 2015 Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia.
25190814 2014 Physical and functional interactions between the histone H3K4 demethylase KDM5A and the nucleosome remodeling and deacetylase (NuRD) complex.
25015565 2014 Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells.
24716659 2014 Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis.
24582965 2014 Histone demethylase RBP2 is critical for breast cancer progression and metastasis.
24442343 2014 Increased progesterone receptor A expression in labouring human myometrium is associated with decreased promoter occupancy by the histone demethylase JARID1A.
24376841 2013 RBP2 induces epithelial-mesenchymal transition in non-small cell lung cancer.
More...