| Tchem | Ephrin type-A receptor 3 |
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung cancer | 4740 | 7.4e-06 |
| malignant mesothelioma | 3232 | 3.9e-05 |
| pancreatic cancer | 2398 | 8.9e-04 |
| primary pancreatic ductal adenocarcinoma | 1109 | 1.4e-03 |
| astrocytic glioma | 2597 | 2.4e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.8e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 6.7e-03 |
| osteosarcoma | 7950 | 9.2e-03 |
| medulloblastoma, large-cell | 6241 | 2.0e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.4e-02 |
| Breast cancer | 3578 | 2.7e-02 |
| pituitary cancer | 1972 | 3.3e-02 |
| Hydrolethalus syndrome | 128 | 3.6e-02 |
| ductal carcinoma in situ | 1745 | 4.3e-02 |
| interstitial lung disease | 298 | 4.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Orofacial cleft | 54 | 0.0 | 3.0 |
| Disease | log2 FC | p |
|---|---|---|
| lung cancer | 4.000 | 7.4e-06 |
| Breast cancer | 2.300 | 2.7e-02 |
| astrocytic glioma | -1.300 | 2.4e-03 |
| ductal carcinoma in situ | -1.500 | 4.3e-02 |
| Hydrolethalus syndrome | -2.566 | 3.6e-02 |
| interstitial lung disease | 1.200 | 4.8e-02 |
| intraductal papillary-mucinous adenoma (... | -2.300 | 6.7e-03 |
| intraductal papillary-mucinous carcinoma... | -2.700 | 3.8e-03 |
| intraductal papillary-mucinous neoplasm ... | -2.700 | 2.4e-02 |
| malignant mesothelioma | -2.000 | 3.9e-05 |
| medulloblastoma, large-cell | 2.000 | 2.0e-02 |
| osteosarcoma | 2.167 | 9.2e-03 |
| pancreatic cancer | 1.800 | 8.9e-04 |
| pituitary cancer | 1.400 | 3.3e-02 |
| primary pancreatic ductal adenocarcinoma | 2.002 | 1.4e-03 |
CHEMBL388978
pKd 7.57
CHEMBL3321809
pKd 8.07
CHEMBL386051
pKd 8.12
CHEMBL2336005
pIC50 8.29
CHEMBL459850
pEC50 8.70
CHEMBL1784637
pIC50 8.92
CHEMBL1230609
pKd 9.00
CHEMBL249097
pKd 10.00
MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQV 1 - 70 CNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQF 71 - 140 TKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLA 141 - 210 MFPDTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKA 211 - 280 LDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLD 281 - 350 TGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSS 351 - 420 PPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRAR 421 - 490 GTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVI 491 - 560 YVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAG 561 - 630 EFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTE 631 - 700 YMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRV 701 - 770 LEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEG 771 - 840 YRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDI 841 - 910 TTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKALETQSKNGP 911 - 980 VPV 981 - 983 //
