Tchem | Ephrin type-A receptor 3 |
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | P-value |
---|---|---|
lung cancer | 4473 | 7.35407311204846E-6 |
malignant mesothelioma | 3163 | 3.87418057192076E-5 |
pancreatic cancer | 2300 | 8.90693229865993E-4 |
primary pancreatic ductal adenocarcinoma | 1271 | 0.00143886902684353 |
medulloblastoma, large-cell | 6234 | 0.00162807055134614 |
astrocytic glioma | 2241 | 0.00240762448348853 |
intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 0.00380674033710543 |
intraductal papillary-mucinous adenoma (IPMA) | 2956 | 0.00667355147635459 |
osteosarcoma | 7933 | 0.0091971376882295 |
Breast cancer | 3099 | 0.0176359034546944 |
intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.0244847802455084 |
pituitary cancer | 1972 | 0.0330409479404939 |
Hydrolethalus syndrome | 128 | 0.0362624571621455 |
ductal carcinoma in situ | 1745 | 0.0427248823858595 |
interstitial lung disease | 292 | 0.0480057264588761 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Orofacial cleft | 38 | 0.0 | 2.0 |
Disease | Target Count |
---|---|
Colorectal Cancer | 62 |
Disease | log2 FC | p |
---|---|---|
interstitial lung disease | 1.200 | 0.048 |
malignant mesothelioma | -2.000 | 0.000 |
astrocytic glioma | -1.300 | 0.002 |
osteosarcoma | 2.167 | 0.009 |
medulloblastoma, large-cell | 2.400 | 0.002 |
primary pancreatic ductal adenocarcinoma | 2.002 | 0.001 |
intraductal papillary-mucinous adenoma (... | -2.300 | 0.007 |
intraductal papillary-mucinous carcinoma... | -2.700 | 0.004 |
intraductal papillary-mucinous neoplasm ... | -2.700 | 0.024 |
Hydrolethalus syndrome | -2.566 | 0.036 |
lung cancer | 4.000 | 0.000 |
Breast cancer | 2.800 | 0.018 |
ductal carcinoma in situ | -1.500 | 0.043 |
pituitary cancer | 1.400 | 0.033 |
pancreatic cancer | 1.800 | 0.001 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Cow | OMA EggNOG |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG |
Chicken | OMA Inparanoid |
Anole lizard | OMA Inparanoid |
CHEMBL388978
pKd 7.57
CHEMBL3321809
pKd 8.07
CHEMBL386051
pKd 8.12
CHEMBL2336005
pIC50 8.29
CHEMBL459850
pEC50 8.70
CHEMBL1784637
pIC50 8.92
CHEMBL1230609
pKd 9.00
CHEMBL249097
pKd 10.00
PMID | Text |
---|---|
26552734 | A novel association between the EPHA3 deletion and prostate cancer risk was observed in Finnish individuals. |
26381449 | This study showed that EPHA3 gene involved in neuronal growth and cerebellum development and associated with neurological and psychological disorders. |
26232493 | EphA3 forms dimers in the absence of ligand binding. |
25993310 | the structure of the ligand-binding domain of the EphA3 receptor in complex with its preferred ligand, ephrin-A5, is reported. |
25420155 | Data indicate that hypoxia increased EphA3 receptor (EphA3) mRNA expression in EphA3+ endometrial multipotent mesenchymal stromal cells (eMSCs). |
25231727 | EphA3 was induced by PC-1 and contributed to the malignant progression of prostate cancer |
23991104 | Based on the knowledge that EPHA4 has been previously shown to rescue SOD1 transgenic mice from ALS phenotype and prolongs survival, EPHA3 may be a promising candidate for therepuetic interventions |
23970317 | EphA3 may represent a novel candidate marker for patient prognosis as well a molecular target for HCC therapy. |
23410976 | High EphA3 expression is associated with glioblastoma multiforme. |
23324396 | EPHA3 mutations may promote tumorigenesis only when key senescence-inducing pathways have been inactivated. |
More... |
MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQV 1 - 70 CNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQF 71 - 140 TKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLA 141 - 210 MFPDTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKA 211 - 280 LDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLD 281 - 350 TGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSS 351 - 420 PPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRAR 421 - 490 GTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVI 491 - 560 YVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAG 561 - 630 EFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTE 631 - 700 YMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRV 701 - 770 LEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEG 771 - 840 YRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDI 841 - 910 TTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKALETQSKNGP 911 - 980 VPV 981 - 983 //
PMID | Year | Title |
---|---|---|
26552734 | 2016 | Germline copy number variation analysis in Finnish families with hereditary prostate cancer. |
26381449 | 2015 | The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients. |
26232493 | 2015 | Unliganded EphA3 dimerization promoted by the SAM domain. |
25993310 | 2015 | Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5. |
25420155 | 2014 | Hypoxia-controlled EphA3 marks a human endometrium-derived multipotent mesenchymal stromal cell that supports vascular growth. |
25231727 | 2014 | EphA3, induced by PC-1/PrLZ, contributes to the malignant progression of prostate cancer. |
24024966 | 2013 | Genome-wide association study of chronic periodontitis in a general German population. |
23991104 | 2013 | Genome-wide copy number variation in sporadic amyotrophic lateral sclerosis in the Turkish population: deletion of EPHA3 is a possible protective factor. |
23970317 | 2013 | High levels of EphA3 expression are associated with high invasive capacity and poor overall survival in hepatocellular carcinoma. |
23410976 | 2013 | EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme. |
More... |