| Tclin | Ephrin type-A receptor 2 |
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
Comments
Property Summary
| Ligand Count | 18 |
| NCBI Gene PubMed Count | 234 |
| PubMed Score | 874.64 |
| PubTator Score | 341.83 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cataract 6, Multiple Types | 1 | 0.0 | 0.0 |
| Disease Progression | 136 | 0.0 | 0.0 |
| LEOPARD syndrome | 20 | 0.0 | 0.0 |
| Neoplasms | 63 | 0.0 | 0.0 |
| Noonan syndrome | 34 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 3.4e-22 |
| lung carcinoma | 2843 | 2.6e-10 |
| nasopharyngeal carcinoma | 1058 | 1.7e-07 |
| psoriasis | 6694 | 1.5e-06 |
| ulcerative colitis | 1819 | 2.0e-06 |
| adrenocortical carcinoma | 1428 | 3.6e-06 |
| pancreatic cancer | 2398 | 2.2e-05 |
| ovarian cancer | 8520 | 1.5e-04 |
| Atopic dermatitis | 952 | 1.8e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.6e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 7.4e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 9.0e-03 |
| group 3 medulloblastoma | 4104 | 3.0e-02 |
| sarcoidosis | 370 | 3.7e-02 |
| chronic rhinosinusitis | 512 | 3.7e-02 |
| spina bifida | 1074 | 4.8e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | -1.053 | 3.6e-06 |
| Atopic dermatitis | 1.100 | 1.8e-04 |
| atypical teratoid / rhabdoid tumor | 1.100 | 9.0e-03 |
| Breast cancer | -1.600 | 3.4e-22 |
| chronic rhinosinusitis | -1.171 | 3.7e-02 |
| group 3 medulloblastoma | 1.400 | 3.0e-02 |
| intraductal papillary-mucinous neoplasm ... | 2.100 | 3.6e-03 |
| lung carcinoma | -1.200 | 2.6e-10 |
| nasopharyngeal carcinoma | -1.200 | 1.7e-07 |
| ovarian cancer | -1.100 | 1.5e-04 |
| pancreatic cancer | 1.400 | 2.2e-05 |
| pancreatic ductal adenocarcinoma liver m... | 1.795 | 7.4e-03 |
| psoriasis | 1.100 | 1.5e-06 |
| sarcoidosis | -1.100 | 3.7e-02 |
| spina bifida | -1.840 | 4.8e-02 |
| ulcerative colitis | 2.000 | 2.0e-06 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA |
dasatinib
pKd 9.07
CHEMBL3577124
pIC50 7.70
CHEMBL1688860
pIC50 7.75
CHEMBL288441
pKd 7.75
CHEMBL3426225
pIC50 7.80
CHEMBL2029988
pKd 7.85
CHEMBL478629
pIC50 7.96
CHEMBL1688861
pIC50 7.96
CHEMBL249097
pKd 8.10
CHEMBL386051
pKd 8.42
CHEMBL1230609
pKd 8.44
CHEMBL566515
pIC50 8.64
CHEMBL1784637
pIC50 9.22
![Structure of compound 20 [PMID: 23489211]](/idg/structure/2ccebace-d2b5-4032-8b6b-dc017a9bff20.svg)
compound 20 [PMID: 23489211]
pIC50 5.66
![Structure of compound 66 [PMID: 19788238]](/idg/structure/34501de2-2fae-4bd2-902e-9ba889583ae5.svg)
compound 66 [PMID: 19788238]
pIC50 8.64
![Structure of compound 8h [PMID: 21561767]](/idg/structure/777ff2aa-9e79-4dda-843f-df9d5f516b30.svg)
compound 8h [PMID: 21561767]
pIC50 9.22
dorsomorphin
pIC50 7.96
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVC 1 - 70 NVMSGDQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFT 71 - 140 KIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAH 141 - 210 FPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVEDACQACSPGF 211 - 280 FKFEASESPCLECPEHTLPSPEGATSCECEEGFFRAPQDPASMPCTRPPSAPHYLTAVGMGAKVELRWTP 281 - 350 PQDSGGREDIVYSVTCEQCWPESGECGPCEASVRYSEPPHGLTRTSVTVSDLEPHMNYTFTVEARNGVSG 351 - 420 LVTSRSFRTASVSINQTEPPKVRLEGRSTTSLSVSWSIPPPQQSRVWKYEVTYRKKGDSNSYNVRRTEGF 421 - 490 SVTLDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHR 491 - 560 RRKNQRARQSPEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKG 561 - 630 MLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGAL 631 - 700 DKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEA 701 - 770 TYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPM 771 - 840 DCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVS 841 - 910 EWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRIAYSLLGLKDQVNTVGIPI 911 - 976 //
