Property Summary

NCBI Gene PubMed Count 433
PubMed Score 1870.46
PubTator Score 997.75

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
lung carcinoma 2844 2.62496820564265E-16
lung adenocarcinoma 2714 2.14244334723094E-8
malignant mesothelioma 3163 2.75755735659557E-7
ovarian cancer 8492 1.29774892190563E-5
juvenile dermatomyositis 1189 3.83429681962112E-5
primary pancreatic ductal adenocarcinoma 1271 5.33433128311347E-5
pancreatic cancer 2300 1.14471820135979E-4
nasopharyngeal carcinoma 1056 1.50696591940251E-4
pituitary cancer 1972 1.97087166312232E-4
ulcerative colitis 2087 2.39561033995141E-4
psoriasis 6685 2.9318873005713E-4
Duchenne muscular dystrophy 602 4.76951044896827E-4
cystic fibrosis 1670 5.87975378708635E-4
limb girdle muscular dystrophy 2I 56 7.85807698948555E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00294751353463471
interstitial cystitis 2299 0.00312122760136667
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00494558878995014
adrenocortical carcinoma 1427 0.00499779467599913
atypical teratoid / rhabdoid tumor 4369 0.00694785935161994
gastric carcinoma 832 0.0105278515103579
ependymoma 2514 0.0108866010662772
glioblastoma 5572 0.0126210481304834
Breast cancer 3099 0.0143435916441618
Atopic dermatitis 944 0.0225465967077745
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0296346855516398
Obesity 616 0.0332186358584641
spina bifida 1064 0.0387130450924992
Becker muscular dystrophy 187 0.0478208948108633



Accession P29279 E1P578 Q6LCY0 Q96A79 Q96QX2 Q9UDL6
Symbols CCN2


PANTHER Protein Class (2)

  Ortholog (13)

Gene RIF (418)

26909983 The gradual increase of CTGF and TGF-beta1 expression levels in liver tissue is associated with liver fibrosis. Early expression of CTGF and TGF-beta1 in biliary epithelial cells may be involved in the pathogenesis of congenital biliary atresia.
26719893 TGF-beta and CCN2 play an important role in IUA formation.
26707502 small interfering RNAmediated silencing of CTGF promoted cell death and suppressed osteosarcoma cell migration and invasion.
26577677 Findings suggest that GDF8 and CTGF may play critical roles in the regulation of proliferative events in human granulosa cells.
26575166 In high-grade serous ovarian tumors the highest level of tumor stromal CTGF expression was correlated with the poorest prognosis. Identify CTGF as a promoter of peritoneal adhesion, likely to mediate metastasis, and a potential therapeutic target in high-grade serous ovarian cancer.
26498181 Studies indicate that the CYR61 CTGF NOV matricellular proteins (CCN family of proteins) comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6 and have been identified in various types of cancer.
26421309 renoprotective therapeutic agents can specifically abolish CCN2 expression in diabetic nephropathy; CCN2 plays a pivotal role in disease progression [review]
26318291 CTGF was able to induce tumor cell epithelial-mesenchymal transition (EMT), and promote stroma deposition of collagen I fibers to stimulate tumor growth and metastasis.
26218313 Report opposing effects of CCN2 and CCN5 on fibroblast proliferation and transdifferentiation induced by TGF-beta.
26192087 Studied how rapamycin affects CCN2 expression and migration of lung fibroblasts in vitro; PI3K and inhibitors were used to determine rapamycin's mechanism of action.

AA Sequence


Text Mined References (434)

PMID Year Title
26909983 2016 Expression of transforming growth factor-?1 and connective tissue growth factor in congenital biliary atresia and neonatal hepatitis liver tissue.
26719893 2015 The Overexpression of TGF-? and CCN2 in Intrauterine Adhesions Involves the NF-?B Signaling Pathway.
26707502 2016 Downregulation of connective tissue growth factor reduces migration and invasiveness of osteosarcoma cells.
26577677 2016 Growth differentiation factor 8 suppresses cell proliferation by up-regulating CTGF expression in human granulosa cells.
26575166 2015 Connective tissue growth factor as a novel therapeutic target in high grade serous ovarian cancer.
26498181 2015 Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review).
26421309 2015 Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy.
26318291 2015 Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition.
26218313 2015 CCN2 and CCN5 exerts opposing effect on fibroblast proliferation and transdifferentiation induced by TGF-?.
26192087 2015 Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinase.