Tclin ADORA2B Adenosine receptor A2b

Protein Summary

Description

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P29275

Gene Name

• ADORA2B

Ensembl ID

• ENST00000304222
• ENSP00000304501
• ENSG00000170425

Symbol

• ADORA2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	1
biological process	0.99
transcription factor perturbation	0.94
PubMedID	0.81
biological term	0.78

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Adenosine Receptor A2b

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Adenosine Receptor / Adenosine Receptor A2b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1305.46   (req: < 5)

Gene RIFs: 115   (req: <= 3)

Antibodies: 279   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1305.46   (req: >= 5)

Gene RIFs: 115   (req: > 3)

Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1207

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8