| Tbio | Protein S100-A2 |
May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 6.7e-17 |
| ependymoma | 4679 | 1.8e-07 |
| psoriasis | 6694 | 1.8e-06 |
| malignant mesothelioma | 3232 | 2.6e-06 |
| lung adenocarcinoma | 2716 | 5.2e-05 |
| ovarian cancer | 8520 | 1.0e-04 |
| Atopic dermatitis | 952 | 1.0e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.7e-04 |
| tuberculosis | 2010 | 1.9e-04 |
| pancreatic cancer | 2398 | 7.9e-04 |
| adult high grade glioma | 3801 | 3.6e-03 |
| glioblastoma | 5792 | 4.2e-03 |
| ductal carcinoma in situ | 1745 | 5.6e-03 |
| Breast cancer | 3578 | 7.0e-03 |
| colon cancer | 1478 | 7.7e-03 |
| subependymal giant cell astrocytoma | 2287 | 1.5e-02 |
| active ulcerative colitis | 764 | 2.1e-02 |
| nasopharyngeal carcinoma | 1058 | 2.1e-02 |
| medulloblastoma, large-cell | 6241 | 2.3e-02 |
| esophageal adenocarcinoma | 737 | 3.2e-02 |
| spina bifida | 1074 | 4.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active ulcerative colitis | 1.038 | 2.1e-02 |
| adult high grade glioma | 1.500 | 3.6e-03 |
| Atopic dermatitis | 1.500 | 1.0e-04 |
| atypical teratoid / rhabdoid tumor | 1.400 | 1.7e-04 |
| Breast cancer | -1.300 | 7.0e-03 |
| colon cancer | 2.700 | 7.7e-03 |
| ductal carcinoma in situ | 2.300 | 5.6e-03 |
| ependymoma | 2.100 | 1.8e-07 |
| esophageal adenocarcinoma | -3.800 | 3.2e-02 |
| glioblastoma | 1.200 | 4.2e-03 |
| lung adenocarcinoma | 2.500 | 5.2e-05 |
| malignant mesothelioma | -1.300 | 2.6e-06 |
| medulloblastoma, large-cell | 1.100 | 2.3e-02 |
| nasopharyngeal carcinoma | -1.700 | 2.1e-02 |
| non-small cell lung cancer | 4.841 | 6.7e-17 |
| ovarian cancer | 3.100 | 1.0e-04 |
| pancreatic cancer | 2.000 | 7.9e-04 |
| psoriasis | 1.100 | 1.8e-06 |
| spina bifida | -2.475 | 4.9e-02 |
| subependymal giant cell astrocytoma | 1.098 | 1.5e-02 |
| tuberculosis | -1.100 | 1.9e-04 |
