Tbio S100A2 Protein S100-A2

Protein Summary

Description

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may have a tumor suppressor function. Chromosomal rearrangements and altered expression of this gene have been implicated in breast cancer. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P29034
• O00266
• Q3KRB9
• Q5RHS8
• Q9BU83

Gene Name

• S100A2

Ensembl ID

• ENST00000368708
• ENSP00000357697
• ENSG00000196754
• ENST00000368709
• ENSP00000357698
• ENST00000368710
• ENSP00000357699
• ENST00000487430
• ENSP00000473260

Symbol

• S100L
• CAN19
• S100L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.92
small molecule perturbation	0.76
protein domain	0.73
tissue sample	0.66
biological term	0.59

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Protein S100-a2

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Protein S100-a2

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Protein S100-a2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.61   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.61   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0