Property Summary

NCBI Gene PubMed Count 288
PubMed Score 13305.56
PubTator Score 10665.84

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count
Neoplastic Cell Transformation 81
Disease Target Count P-value
non-small cell lung cancer 2798 6.13304325738669E-17
lung adenocarcinoma 2714 1.28268982819096E-10
glioblastoma 5572 2.86700772675791E-5
psoriasis 6685 1.52738286361302E-4
lung cancer 4473 5.41588709586611E-4
ductal carcinoma in situ 1745 0.00110762416201812
invasive ductal carcinoma 2950 0.0013566033880668
Atopic dermatitis 944 0.00444667796077755
Disease Target Count Z-score Confidence
Heart disease 279 3.517 1.8


  Differential Expression (8)

Disease log2 FC p
psoriasis -2.300 0.000
glioblastoma 1.100 0.000
Atopic dermatitis -1.100 0.004
non-small cell lung cancer -1.314 0.000
lung cancer -1.300 0.001
lung adenocarcinoma -2.000 0.000
invasive ductal carcinoma -1.900 0.001
ductal carcinoma in situ -1.500 0.001



  Ortholog (10)

Gene RIF (255)

26930650 Autophagy in CD34+ cells from aplastic anemia patients is impaired; autophagy is required for the survival of CD34+ cells; impaired autophagy in CD34+ hematopoietic progenitor cells may play an important role in the pathogenesis of aplastic anemia.
26886640 overexpression in glioma tissues associated closely with higher WHO grade (III + IV) [review]
26861446 Metformin simultaneously increases VEGFA and reduces CXCL10 and TIMP1 in CD34(+) cells in a model of the diabetic state combined with hypoxia to stimulate angiogenesis.
26769093 Studied the relationship between serum alkaline phosphatase, circulating CD34-positive cells and body mass index.
26676225 High VEGF expression was subsequently correlated with a short overall survival rate for patients exhibiting lymph node metastasis (P=0.0128); however, there was no significant difference in overall survival rate regarding the expression levels of TP and CD34
26626992 Asthmatics with reduced lung function had a higher frequency of Lin(-) CD34(hi) CD117(int/hi) Fc epsilon RI(+) blood mast cell progenitors than asthmatics with normal lung function.
26625754 ICAM-1, VCAM-1 and CD34 are useful biomarkers in evaluation of vascular and inflammatory lesions such as gingival pyogenic granuloma and the results indicate the role of these biomarkers in pathogenesis of oral pyogenic granuloma.
26617797 CD34(+) cells lowering expression of TET2 may play an oncogenic role on myeloid tumor and CD3(+) T cells of myelodysplastic syndrome patients may be derived from the malignant clone.
26617768 Immunohistochemistry results indicate that combination with ALDH1 and STAT6 can improve the diagnostic value of CD34 for solitary fibrous tumors.
26394034 Data indicate only the glycoproteins CD34+/CD71low population showed statistically significant differences between Diamond-Blackfan Anaemia (DBA) patients and controls.

AA Sequence

GKASVNRGAQENGTGQATSRNGHSARQHVVADTEL                                       351 - 385

Text Mined References (288)

PMID Year Title
26930650 2016 Impaired Autophagy in Adult Bone Marrow CD34+ Cells of Patients with Aplastic Anemia: Possible Pathogenic Significance.
26886640 2016 CD34 Over-Expression is Associated With Gliomas' Higher WHO Grade.
26861446 2016 Metformin improves the angiogenic potential of human CD34? cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction.
26769093 2016 Association between circulating CD34-positive cells and serum alkaline phosphatase in relation to body mass index for elderly Japanese men.
26676225 2016 Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer.
26626992 2016 Lin- CD34hi CD117int/hi Fc?RI+ cells in human blood constitute a rare population of mast cell progenitors.
26625754 2015 Immunohistochemical Evaluation of Angiogenesis Related Markers in Pyogenic Granuloma of Gingiva.
26617797 2015 Down-regulation of TET2 in CD3? and CD34? cells of myelodysplastic syndromes and enhances CD34? cells proliferation.
26617768 2015 Immunohistochemical evaluation of stem cell markers and signal transducer and activator of transcription 6 (STAT6) in solitary fibrous tumors.
26394034 2015 Immunophenotypic Profiling of Erythroid Progenitor-Derived Extracellular Vesicles in Diamond-Blackfan Anaemia: A New Diagnostic Strategy.