Tclin HSD11B1 Corticosteroid 11-beta-dehydrogenase isozyme 1

Protein Summary

Description

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity). The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]

Uniprot Accession IDs

• P28845
• B2R9Z1
• D3DT89

Gene Name

• HSD11B1

Ensembl ID

• ENST00000367027
• ENSP00000355994
• ENSG00000117594
• ENST00000367028
• ENSP00000355995

Symbol

• HSD11
• HSD11L
• SDR26C1
• HDL
• 11-DH
• HSD11
• HSD11B
• HSD11L
• CORTRD2
• SDR26C1
• 11-beta-HSD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
biological term	0.95
disease perturbation	0.87
chemical	0.81
drug	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1116.19   (req: < 5)

Gene RIFs: 220   (req: <= 3)

Antibodies: 389   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1116.19   (req: >= 5)

Gene RIFs: 220   (req: > 3)

Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2745

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4