Tchem LAP3 Cytosol aminopeptidase

Protein Summary

Description

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Uniprot Accession IDs

• P28838
• B3KMQ3
• Q6IAM6
• Q6P0L6
• Q9UQE3

Gene Name

• LAP3

Ensembl ID

• ENST00000226299
• ENSP00000226299
• ENSG00000002549
• ENST00000606142
• ENSP00000476028
• ENST00000618908
• ENSP00000481000

Symbol

• LAPEP
• PEPS
• LAP
• PEPS
• LAPEP
• HEL-S-106

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
disease perturbation	0.87
transcription factor binding site profile	0.79
PubMedID	0.77
kinase perturbation	0.76

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Cytosol Aminopeptidase

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Cytosol Aminopeptidase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 513.04   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 218   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 513.04   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 30

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1