RXRB
Retinoic acid receptor RXR-beta
Protein Summary
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE). This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
- ENST00000374680
- ENSP00000363812
- ENSG00000204231
- ENST00000374685
- ENSP00000363817
- ENST00000383216
- ENSP00000372703
- ENSG00000206289
- ENST00000383217
- ENSP00000372704
- ENST00000415157
- ENSP00000402506
- ENSG00000228333
- ENST00000415909
- ENSP00000410468
- ENSG00000235712
- ENST00000431161
- ENSP00000393286
- ENST00000431820
- ENSP00000411238
- ENSG00000231321
- ENST00000436753
- ENSP00000415199
- ENSG00000227322
- ENST00000443603
- ENSP00000402590
- ENST00000455462
- ENSP00000400104
- ENST00000456244
- ENSP00000393870
- NR2B2
- NR2B2
- DAUDI6
- RCoR-1
- H-2RIIBP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
interacting protein | 0.9 | ||
disease perturbation | 0.87 | ||
protein domain | 0.85 | ||
biological process | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.7 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 321 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.7 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 321 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 70
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3