Property Summary

NCBI Gene PubMed Count 24
PubMed Score 27.00
PubTator Score 29.98

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (4)

Disease Target Count P-value
psoriasis 6685 1.16810761663788E-75
lung carcinoma 2844 3.90726978290512E-33
non-small cell lung cancer 2798 1.14858686695672E-31
lung adenocarcinoma 2714 7.10872516166086E-19
posterior fossa group B ependymoma 1530 2.13063085687268E-9
lung cancer 4473 9.85318375595967E-8
Atopic dermatitis 944 1.3895664779522E-6
intraductal papillary-mucinous carcinoma (IPMC) 2988 3.74793242597018E-6
interstitial cystitis 2299 4.78889349855974E-6
pilocytic astrocytoma 3086 5.50715832827559E-5
pancreatic cancer 2300 2.3960763519282E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 2.45792622442407E-4
atypical teratoid/rhabdoid tumor 1095 2.66376130662186E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 5.03188841709002E-4
ductal carcinoma in situ 1745 5.97827647121591E-4
cutaneous lupus erythematosus 1056 0.00142134318395155
invasive ductal carcinoma 2950 0.00226821796138332
primary pancreatic ductal adenocarcinoma 1271 0.00328482658457135
nephrosclerosis 329 0.00476086775332173
gastric carcinoma 832 0.00930806783786613

Expression

Synonym

Accession P28330 B2R8T3 Q8IUN8 LCAD
Symbols LCAD
ACAD4

Gene

PANTHER Protein Class (2)

  Ortholog (14)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid

Gene RIF (8)

PMID Text
24591516 the fatty acid oxidation pathway and LCAD are factors contributing to the pathophysiology of pulmonary disease
24121500 Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.
20877624 Observational study of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20363655 LCAD is minimally expressed in human skeletal muscle and likely does not play a significant role in long-chain fatty acid oxidation.
20037589 Observational study of gene-disease association. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
18660489 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQE      1 - 70
EVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAYSNCSGPGFSIHSGI     71 - 140
VMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLS    141 - 210
DVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKG    211 - 280
FYYIMKELPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDN    281 - 350
CLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKE    351 - 420
LIAREIVFDK                                                                421 - 430
//

Text Mined References (28)

PMID Year Title
24816252 2014 An atlas of genetic influences on human blood metabolites.
24591516 2014 Long-chain acyl-CoA dehydrogenase deficiency as a cause of pulmonary surfactant dysfunction.
24586186 2014 Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24121500 2013 Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site.
23281178 2013 A genome-wide assessment of variability in human serum metabolism.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20363655 2010 Low expression of long-chain acyl-CoA dehydrogenase in human skeletal muscle.
20037589 2010 A genome-wide perspective of genetic variation in human metabolism.
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