Tbio ATP6V0C V-type proton ATPase 16 kDa proteolipid subunit

Protein Summary

Description

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• P27449
• Q6FH26
• V-ATPase 16 kDa proteolipid subunit

Gene Name

• ATP6V0C

Ensembl ID

• ENST00000330398
• ENSP00000329757
• ENSG00000185883

Symbol

• ATP6C
• ATP6L
• ATPL
• ATPL
• VATL
• VPPC
• Vma3
• ATP6C
• ATP6L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
kinase perturbation	0.97
molecular function	0.97
transcription factor perturbation	0.97
cellular component	0.87

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Atp Synthase / V-type Proton Atpase 16 Kda Proteolipid Subunit

Protein / Hydrolase / V-type Proton Atpase 16 Kda Proteolipid Subunit

DTO Classes

Protein / Transporter / F-type And V-type Atpases / V-type Atpase / V-type Proton Atpase 16 Kda Proteolipid Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.15   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 78   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.15   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0