Property Summary

NCBI Gene PubMed Count 93
PubMed Score 96.59
PubTator Score 76.03

Knowledge Summary

Patent (21,545)


  Disease Sources (4)

Disease Target Count
Microsatellite Instability 12
Disease Target Count P-value
breast carcinoma 1614 4.68500010898396E-18
Breast cancer 3099 5.38272948104549E-13
ulcerative colitis 2087 6.0946002489787E-7
osteosarcoma 7933 2.83799414907189E-5
pilocytic astrocytoma 3086 7.06868068056844E-5
adult high grade glioma 2148 1.25051071177013E-4
glioblastoma 5572 1.90136467513869E-4
ependymoma 2514 2.64202305708803E-4
atypical teratoid / rhabdoid tumor 4369 3.64156918405134E-4
interstitial cystitis 2299 4.42768129178188E-4
ovarian cancer 8492 6.91042428724035E-4
invasive ductal carcinoma 2950 0.00124928187636246
astrocytic glioma 2241 0.0166507871699031
acute myeloid leukemia 785 0.027185358124257
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
pre-eclampsia 67 3.591 1.8
Multiple synostoses syndrome 8 3.129 1.6


  Differential Expression (14)

Disease log2 FC p
astrocytic glioma -1.400 0.017
glioblastoma -1.700 0.000
osteosarcoma -2.825 0.000
ependymoma -1.200 0.000
atypical teratoid / rhabdoid tumor -2.200 0.000
interstitial cystitis -1.300 0.000
adult high grade glioma -1.600 0.000
pilocytic astrocytoma -1.100 0.000
breast carcinoma -1.100 0.000
Breast cancer -1.300 0.000
invasive ductal carcinoma -1.700 0.001
acute myeloid leukemia -2.100 0.027
ulcerative colitis -1.500 0.000
ovarian cancer 1.800 0.001


Accession P27037 B2RAB8 B4DWQ2 D3DP85 Q53TH4 Q6NWV2 Q92474
Symbols ACVR2



3Q4T   3SOC   4ASX  

  Ortholog (12)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid

  TechDev Info (1)

Gary Johnson Kinome profile via MIB/MS Technology

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448

Gene RIF (38)

26677222 Data suggest ALK1 and ACVR2A/ACVR2B, acting as BMP9 co-receptors, rearrange pro-domains of BMP9--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling.
26086422 Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors.
26047946 Activin A inhibited signaling by BMP-6 and BMP-9 by competing for type 2 receptors ACVR2A and ACVR2B.
25659497 Data suggest that an SNP in promoter region of ACVR2A (rs1424954, the pre-eclampsia susceptibility allele) down-regulates 1) expression of ACVR2A in trophoblasts and 2) signal transduction in response to excess activin-A (as seen in pre-eclampsia).
25499008 The gene ACVR2A was associated with the more severe early onset preeclampsia.
23633461 For ACVR2A SNPs (rs10497025, rs1128919, rs13430086), no statistically significant difference was found between preeclampsia and control groups in terms of genotype and allele frequencies.
23263486 ACVR2A was identified as a subnetwork component in functional association network analysis.
22949641 ACVR2A interaction with Nodal and ADMP regulates head development from the 'organizer', a restricted group of cells in the embryo.
22848350 ACVR2A showed statistically significant differential dose-expression relationship.
22723898 This is the first report on the function of miR-195 in human placental trophoblast cells which reveals an invasion-promoting effect of the small RNA via repressing ActRIIA.

AA Sequence

TEDIVTVVTMVTNVDFPPKESSL                                                   491 - 513

Text Mined References (96)

PMID Year Title
26677222 2016 Rapid Activation of Bone Morphogenic Protein 9 by Receptor-mediated Displacement of Pro-domains.
26086422 2015 Myostatin, follistatin and activin type II receptors are highly expressed in adenomyosis.
26047946 2015 Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.
25659497 2015 ACVR2A promoter polymorphism rs1424954 in the Activin-A signaling pathway in trophoblasts.
25499008 2015 Association between ACVR2A and early-onset preeclampsia: replication study in a Northeastern Brazilian population.
23633461 2013 Polymorphisms in the activin A receptor type 2A gene affect the onset time and severity of preeclampsia in the Turkish population.
23263486 2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
22949641 2012 Self-regulation of the head-inducing properties of the Spemann organizer.
22848350 2012 Iodine-131 dose dependent gene expression in thyroid cancers and corresponding normal tissues following the Chernobyl accident.
22723898 2012 Downregulated miR-195 detected in preeclamptic placenta affects trophoblast cell invasion via modulating ActRIIA expression.