Tchem MGAT1 Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Protein Summary

Description

Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P26572
• A8K404
• B3KRU8
• D3DWR1
• Q6IBE3

Gene Name

• MGAT1

Ensembl ID

• ENST00000307826
• ENSP00000311888
• ENSG00000131446
• ENST00000333055
• ENSP00000332073
• ENST00000393340
• ENSP00000377010
• ENST00000427865
• ENSP00000402838
• ENST00000446023
• ENSP00000404718

Symbol

• GGNT1
• GLCT1
• GLYT1
• MGAT
• GnTI
• MGAT
• GLCT1
• GLYT1
• GNT-1
• GNT-I
• GLCNAC-TI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.96
co-expressed gene	0.85
kinase perturbation	0.84
transcription factor binding site profile	0.77
cellular component	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.56   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 262   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.56   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0