Property Summary

NCBI Gene PubMed Count 54
PubMed Score 99.49
PubTator Score 51.04

Knowledge Summary


No data available


  Disease Sources (1)

Disease Target Count P-value
ovarian cancer 8492 4.01212064166198E-7
malignant mesothelioma 3163 1.06281165943541E-6
osteosarcoma 7933 3.76833684369206E-5
psoriasis 6685 1.50163309840597E-4
atypical teratoid / rhabdoid tumor 4369 2.14978287000692E-4
adult high grade glioma 2148 0.00156930656762827
astrocytoma 1493 0.0056334942110968
group 3 medulloblastoma 2254 0.00740379945347419
aldosterone-producing adenoma 664 0.0169485611945096
subependymal giant cell astrocytoma 2287 0.0493870361406826


  Differential Expression (10)

Disease log2 FC p
malignant mesothelioma -1.200 0.000
astrocytoma -1.300 0.006
psoriasis -2.000 0.000
osteosarcoma -1.399 0.000
group 3 medulloblastoma 1.400 0.007
atypical teratoid / rhabdoid tumor -1.200 0.000
adult high grade glioma -1.100 0.002
aldosterone-producing adenoma -1.244 0.017
subependymal giant cell astrocytoma -1.338 0.049
ovarian cancer -2.100 0.000


Accession P25208 A8K7B9 Q96IY8
Symbols HAP3



1N1J   4AWL   4CSR  

  Ortholog (12)

Gene RIF (17)

26509926 Presence of NF-Y transcription factor plays a pivotal role in transcriptional regulation of ID genes in development.
26039627 NF-YB transcription factor was identified as a novel direct E2F1 target.
23595228 The NF-Y complex is asymmetric, with NF-YB binding approximately 15 bp downstream from the CCAAT motif.
23332751 The crystal structure of NF-Y bound to a 25 bp CCAAT oligonucleotide shows that the histone-fold domains dimer binds to the DNA sugar-phosphate backbone, mimicking the nucleosome H2A/H2B-DNA assembly; NF-YA both binds to NF-YB/NF-YC and inserts an alpha helix deeply into the DNA minor groove, providing sequence-specific contacts to the CCAAT box.
22132193 Transcriptional repression mediated by IER5 regulates Cdc25B expression levels via the release of NF-YB and p300 in acute myeloid leukemia.
21445285 NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L
21252292 MicroRNA-485-3p regulates drug responsiveness by decreasing nuclear factor-YB expression, which in turn negatively regulates DNA topoisomerase IIalpha.
20965718 Observational study of gene-disease association. (HuGE Navigator)
18480411 CBF-A is a novel transacting factor required for cytoplasmic mRNA transport and localization
18275041 trichostatin A activates the transcription of TSP1 gene through the binding of transcription factor CBF to CCAAT box and the enhanced histone acetylation.

AA Sequence


Text Mined References (56)

PMID Year Title
26509926 2015 Epigenetic role of CCAAT box-binding transcription factor NF-Y on ID gene family in human embryonic carcinoma cells.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26039627 2015 E2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional Program.
25416956 2014 A proteome-scale map of the human interactome network.
25343990 2015 Genome-wide association study of selenium concentrations.
23734815 2013 Fludarabine treatment favors the retention of miR-485-3p by prostate cancer cells: implications for survival.
23595228 2013 NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors.
23332751 2013 Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination.
22132193 2011 Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia.
21988832 2011 Toward an understanding of the protein interaction network of the human liver.