| Tbio | DNA replication licensing factor MCM3 |
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.4e-12 |
| glioblastoma | 5792 | 5.4e-08 |
| posterior fossa group A ependymoma | 468 | 8.9e-08 |
| malignant mesothelioma | 3232 | 1.1e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.1e-06 |
| group 3 medulloblastoma | 4104 | 2.8e-06 |
| medulloblastoma, large-cell | 6241 | 3.3e-06 |
| pediatric high grade glioma | 1064 | 1.2e-05 |
| primitive neuroectodermal tumor | 3035 | 2.1e-04 |
| colon cancer | 1478 | 2.4e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 9.4e-04 |
| adrenocortical carcinoma | 1428 | 1.8e-03 |
| Breast cancer | 3578 | 2.6e-02 |
| lung cancer | 4740 | 3.0e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | 1.074 | 1.8e-03 |
| atypical teratoid / rhabdoid tumor | 1.600 | 1.1e-06 |
| Breast cancer | 2.500 | 2.6e-02 |
| colon cancer | 1.300 | 2.4e-04 |
| glioblastoma | 1.300 | 5.4e-08 |
| group 3 medulloblastoma | 2.100 | 2.8e-06 |
| intraductal papillary-mucinous carcinoma... | 1.500 | 9.4e-04 |
| lung cancer | 1.500 | 3.0e-02 |
| malignant mesothelioma | 1.600 | 1.1e-07 |
| medulloblastoma, large-cell | 2.000 | 3.3e-06 |
| non-small cell lung cancer | 1.049 | 1.4e-12 |
| pediatric high grade glioma | 1.300 | 1.2e-05 |
| posterior fossa group A ependymoma | 1.100 | 8.9e-08 |
| primitive neuroectodermal tumor | 1.400 | 2.1e-04 |
MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAF 1 - 70 EELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPK 71 - 140 VVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPA 141 - 210 GQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAED 211 - 280 IAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVA 281 - 350 KSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRT 351 - 420 AIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMD 421 - 490 PEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKE 491 - 560 KMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAK 561 - 630 ARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAK 631 - 700 DGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTE 701 - 770 SINRDSEEPFSSVEIQAALSKMQDDNQVMVSEGIIFLI 771 - 808 //
