| Tchem | Platelet-activating factor receptor |
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Comments
Property Summary
| Ligand Count | 225 |
| NCBI Gene PubMed Count | 85 |
| PubMed Score | 116.14 |
| PubTator Score | 254.01 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Polycystic ovary syndrome | 360 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1187 | 6.1e-07 |
| tuberculosis | 2010 | 1.0e-05 |
| ovarian cancer | 8520 | 1.1e-05 |
| hepatocellular carcinoma | 547 | 2.1e-05 |
| medulloblastoma, large-cell | 6241 | 1.0e-04 |
| pancreatic cancer | 2398 | 1.2e-04 |
| pancreatic carcinoma | 562 | 1.2e-04 |
| cystic fibrosis | 1696 | 2.4e-04 |
| fascioscapulohumeral muscular dystrophy | 100 | 6.7e-04 |
| Amyotrophic lateral sclerosis | 451 | 1.5e-03 |
| interstitial cystitis | 2312 | 2.4e-03 |
| psoriasis | 6694 | 5.9e-03 |
| osteosarcoma | 7950 | 7.7e-03 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 7.9e-03 |
| gastric carcinoma | 807 | 1.8e-02 |
| active ulcerative colitis | 764 | 2.1e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active ulcerative colitis | 1.146 | 2.1e-02 |
| Amyotrophic lateral sclerosis | -1.089 | 1.5e-03 |
| cystic fibrosis | 1.100 | 2.4e-04 |
| fascioscapulohumeral muscular dystrophy | -1.100 | 6.7e-04 |
| gastric carcinoma | 1.300 | 1.8e-02 |
| hepatocellular carcinoma | 1.300 | 2.1e-05 |
| interstitial cystitis | 1.100 | 2.4e-03 |
| juvenile dermatomyositis | -1.143 | 6.1e-07 |
| medulloblastoma, large-cell | -1.300 | 1.0e-04 |
| mucosa-associated lymphoid tissue lympho... | 1.052 | 7.9e-03 |
| osteosarcoma | -1.066 | 7.7e-03 |
| ovarian cancer | -1.400 | 1.1e-05 |
| pancreatic cancer | 1.900 | 1.2e-04 |
| pancreatic carcinoma | 1.900 | 1.2e-04 |
| psoriasis | 1.500 | 5.9e-03 |
| tuberculosis | 1.100 | 1.0e-05 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG |
CHEMBL33139
pIC50 7.00
CHEMBL300463
pIC50 7.00
CHEMBL283152
pIC50 7.00
CHEMBL20141
pIC50 7.00
CHEMBL36269
pIC50 7.00
CHEMBL37809
pIC50 7.00
CHEMBL143914
pIC50 7.00
CHEMBL20591
pIC50 7.00
CHEMBL288098
pIC50 7.00
CHEMBL369194
pIC50 7.00
CHEMBL52821
pIC50 7.00
CHEMBL280164
pIC50 7.03
CHEMBL160571
pIC50 7.04
CHEMBL328833
pIC50 7.05
CHEMBL20690
pIC50 7.05
CHEMBL57510
pIC50 7.07
CHEMBL286229
pIC50 7.10
CHEMBL296169
pIC50 7.10
CHEMBL281780
pIC50 7.10
CHEMBL21026
pIC50 7.13
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITL 1 - 70 PLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLV 71 - 140 IWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVII 141 - 210 RTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLC 211 - 280 LLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN 281 - 342 //
