Tchem CXCR2 C-X-C chemokine receptor type 2

Protein Summary

Description

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• P25025
• Q8IUZ1
• Q9P2T6
• Q9P2T7
• CXC-R2

Gene Name

• CXCR2

Ensembl ID

• ENST00000318507
• ENSP00000319635
• ENSG00000180871

Symbol

• IL8RB
• CD182
• IL8R2
• IL8RA
• IL8RB
• CMKAR2
• CDw128b

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein)	1
biological process	0.94
gene perturbation	0.9
phenotype	0.79
protein domain	0.73

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Chemokine Receptor / C-x-c Chemokine Receptor Type 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1037.19   (req: < 5)

Gene RIFs: 294   (req: <= 3)

Antibodies: 909   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1037.19   (req: >= 5)

Gene RIFs: 294   (req: > 3)

Antibodies: 909   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 510

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0