Tchem CXCR1 C-X-C chemokine receptor type 1

Protein Summary

Description

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P25024
• B2R6Q3
• Q2YEF8
• Q2YEG4
• Q2YEG5
• Q2YEG7
• Q2YEG8
• Q53R18
• Q6IN95
• Q8N6T6
• Q9P2T8
• Q9P2T9
• Q9P2U0
• Q9P2U1
• Q9P2U2
• CXC-R1

Gene Name

• CXCR1

Ensembl ID

• ENST00000295683
• ENSP00000295683
• ENSG00000163464

Symbol

• CMKAR1
• IL8RA
• C-C
• CD128
• CD181
• CKR-1
• IL8R1
• IL8RA
• CMKAR1
• IL8RBA
• CDw128a
• C-C-CKR-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.87
ligand (protein)	0.85
protein domain	0.73
cell type or tissue	0.7
molecular function	0.7

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Chemokine Receptor / C-x-c Chemokine Receptor Type 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 511.77   (req: < 5)

Gene RIFs: 155   (req: <= 3)

Antibodies: 549   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 511.77   (req: >= 5)

Gene RIFs: 155   (req: > 3)

Antibodies: 549   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 95

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2