Tchem CCNE1 G1/S-specific cyclin-E1

Protein Summary

Description

Essential for the control of the cell cycle at the G1/S (start) transition. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• P24864
• A8K684
• Q14091
• Q8NFG1
• Q92501
• Q9UD21

Gene Name

• CCNE1

Ensembl ID

• ENST00000262643
• ENSP00000262643
• ENSG00000105173
• ENST00000444983
• ENSP00000410179

Symbol

• CCNE
• CCNE
• pCCNE1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
virus perturbation	0.94
PubMedID	0.92
biological term	0.84
kinase perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / G1/s-specific Cyclin-e1

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / G1/s-specific Cyclin-e1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 470.35   (req: < 5)

Gene RIFs: 285   (req: <= 3)

Antibodies: 1089   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 470.35   (req: >= 5)

Gene RIFs: 285   (req: > 3)

Antibodies: 1089   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0