Property Summary

NCBI Gene PubMed Count 142
PubMed Score 346.58
PubTator Score 241.57

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
posterior fossa group A ependymoma 1511 1.56015439345478E-10
non-small cell lung cancer 2798 2.80734329652015E-9
malignant mesothelioma 3163 1.36397866278864E-8
cystic fibrosis 1670 2.03462672610308E-8
pilocytic astrocytoma 3086 4.36416653828618E-7
ulcerative colitis 2087 2.67956266202827E-6
ovarian cancer 8492 3.9089575376577E-6
psoriasis 6685 7.85952553408682E-6
primary pancreatic ductal adenocarcinoma 1271 1.09035972505983E-5
atypical teratoid / rhabdoid tumor 4369 1.57247029748757E-5
pediatric high grade glioma 2712 2.11504201350396E-5
glioblastoma 5572 2.33619510914058E-5
Amyotrophic Lateral Sclerosis 432 4.98728382235566E-5
Atopic dermatitis 944 9.58475086473992E-5
pituitary cancer 1972 1.27418072699358E-4
pancreatic cancer 2300 1.37207796151807E-4
sonic hedgehog group medulloblastoma 1482 2.73220695678932E-4
adrenocortical carcinoma 1427 4.55157768062665E-4
dermatomyositis 967 0.00159993945267334
nephrosclerosis 329 0.00160254419992342
Down syndrome 548 0.00164730100472239
primitive neuroectodermal tumor 3031 0.00687987622591032
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00726247534756292
interstitial cystitis 2299 0.00778417375613417
osteosarcoma 7933 0.00812218105809575
active Crohn's disease 918 0.00821114609190689
invasive ductal carcinoma 2950 0.0088770609220771
ductal carcinoma in situ 1745 0.0114380406389649
mucosa-associated lymphoid tissue lymphoma 480 0.0126560750497382
limb girdle muscular dystrophy 2I 56 0.015714123689895
medulloblastoma, large-cell 6234 0.0303544105398951
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0331240431851701
interstitial lung disease 292 0.0336773472569306
astrocytoma 1493 0.0355112777938074
Becker muscular dystrophy 187 0.0422501228105166
Disease Target Count Z-score Confidence
Acquired metabolic disease 267 0.0 2.0
Disease Target Count Z-score Confidence
Cancer 2346 3.905 2.0



Accession P24593 Q5U0A3 IBP-5
Symbols IBP5



1BOE   1H59  

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG
Zebrafish OMA Inparanoid

 GWAS Trait (1)

Gene RIF (106)

26103640 data provide further insights into the role of cellular compartmentalization in IGFBP-5-induced fibrosis
26010068 Results shed light on the mechanism of IGFBP5 as a potential tumor-suppressor in melanoma progression.
25827480 Demethylation of IGFBP5 by Histone Demethylase KDM6B Promotes Mesenchymal Stem Cell-Mediated Periodontal Tissue Regeneration by Enhancing Osteogenic Differentiation and Anti-Inflammation Potentials.
25603050 miR-204-5p suppresses IGFBP5 expression by direct binding to the 3' untranslated region.
25548030 Our results suggest that rs6214 on the IGF1 gene and rs2854744 near the IGFBP3 gene potentially play an important role with ASMI in Taiwanese older adults in a metropolitan area.
25475528 Data indicate co-localization of insulin-like growth factor binding proteins IGFBP-4, IGFBP-5 in the syncytiotrophoblast layer of first trimester placental villi as early as 5 weeks of gestational age.
25422220 IGFBP5 mRNA expression is a good indicator in clinical outcome of breast cancer patients.
25248036 rs4442975 at 2q35 flanks a transcriptional enhancer that physically interacts with the promoter of IGFBP5. Evidence suggests that the g-allele confers increased breast cancer susceptibility through relative downregulation of IGFBP5.
25007054 IGFBP-5 may be a negative modulator of RASSF1C/ PIWIL1 growth-promoting activities.
24551065 IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis.

AA Sequence


Text Mined References (144)

PMID Year Title
26103640 2015 IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF.
26091039 2015 A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
26010068 2015 Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells.
25827480 2015 Demethylation of IGFBP5 by Histone Demethylase KDM6B Promotes Mesenchymal Stem Cell-Mediated Periodontal Tissue Regeneration by Enhancing Osteogenic Differentiation and Anti-Inflammation Potentials.
25603050 2015 MiR-204-5p suppresses cell proliferation by inhibiting IGFBP5 in papillary thyroid carcinoma.
25548030 2015 Insulinlike Growth Factor-1 and Its Binding Protein-3 Polymorphisms Predict Circulating IGF-1 Level and Appendicular Skeletal Muscle Mass in Chinese Elderly.
25475528 2014 IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells.
25436638 2014 Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network.
25422220 2014 Detection of PIK3CA gene mutations with HRM analysis and association with IGFBP-5 expression levels in breast cancer.
25248036 2014 Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.