Protein Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
- ENST00000425687
- ENSP00000388736
- ENSG00000059377
- CYP5
- CYP5A1
- TS
- TXS
- CYP5
- THAS
- TXAS
- CYP5A1
- GHOSAL
- BDPLT14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor | 0.86 | ||
disease | 0.73 | ||
transcription factor binding site profile | 0.73 | ||
tissue sample | 0.72 | ||
molecular function | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 237.15 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 405 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 237.15 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 405 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 670
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 9