Property Summary

NCBI Gene PubMed Count 193
PubMed Score 1672.03
PubTator Score 600.15

Knowledge Summary

Patent (27,777)


  Disease Sources (8)

Disease Target Count P-value
non-small cell lung cancer 2798 2.48006087211851E-35
breast carcinoma 1614 1.00750170904918E-32
lung adenocarcinoma 2714 4.40489199849249E-26
astrocytoma 1493 3.53393583133369E-13
posterior fossa group B ependymoma 1530 5.14067107976492E-8
non-inflammatory breast cancer 208 4.0999066290437E-7
group 4 medulloblastoma 1875 1.27256718496951E-6
medulloblastoma, large-cell 6234 3.26445845002008E-6
lung cancer 4473 4.01834152497836E-5
ductal carcinoma in situ 1745 7.50501880209607E-5
lung carcinoma 2844 8.66031723225291E-5
invasive ductal carcinoma 2950 1.15781725780791E-4
tuberculosis and treatment for 3 months 327 2.31596513432637E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 3.43930910198531E-4
ovarian cancer 8492 4.4352732985528E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 5.75282182398902E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 7.85431023114122E-4
ulcerative colitis 2087 8.2739172686741E-4
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0025357066844511
Down syndrome 548 0.00266601506115719
Pick disease 1893 0.00452725469878051
nephrosclerosis 329 0.00913941033036575
adrenocortical carcinoma 1427 0.0115742117278419
adrenocortical adenoma 134 0.0137768138665476
Multiple myeloma 1328 0.0146385061379728
oligodendroglioma 2849 0.015953799061696
colon cancer 1475 0.0256945217153466
cystic fibrosis and chronic rhinosinusitis 213 0.035218263219258
urothelial carcinoma 318 0.035384681494311
gastric carcinoma 832 0.0485135735342456
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Waardenburg's syndrome 16 5.805 2.9
Disease Target Count
Waardenburg syndrome 4A 1



Accession P24530 A2A2Z8 A8K3T4 O15343 Q59GB1 Q5W0G9 Q8NHM6 Q8NHM7 Q8NHM8 Q8NHM9 Q9UD23 Q9UQK3 ET-B
Symbols ETB


PANTHER Protein Class (2)

  Ortholog (13)

  TechDev Info (1)

MLP Assay (14)

AID Type Active / Inconclusive / Inactive Description
1788 other 0 / 0 / 0 Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Ancillary Activity
1921 other 2 / 0 / 0 Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator: Ancillary Activity
624355 other 0 / 0 / 0 Late stage results from the probe development efforts to identify dual inhibitors of signal transducer and activator of transcription 3 (STAT3) and nuclear factor NF-kappa-B (NF-kB): Cell-based radioligand binding assay to determine the binding affinities for selected transporters, receptors, and GPCRs
624406 other 0 / 0 / 0 Late stage results from the probe development effort to identify inhibitors of Hepatitis C Virus (HCV) core protein dimerization: Cell-based radioligand binding assay to determine the binding affinities for selected transporters, receptors, and GPCRs
686924 other 0 / 0 / 1 ML347 Eurofin Panel Assay for BMP Inhibitor (Probe Compound)
686925 other 0 / 0 / 1 ML352 Eurofin Panel Assay for Choline Transporter Inhibitor (Probe Compound)
686926 other 0 / 0 / 1 ML354 Eurofin Panel Assay for PAR4 Antagonists Inhibitor (Probe Compound)
686927 other 0 / 0 / 1 ML353 Eurofin Panel Assay for mGlu5 SAM Inhibitor (Probe Compound)
743249 screening 1 / 0 / 0 Development of the First Potent, Selective and CNS penetrant M5 Negative Allosteric Modulator (NAM)
743250 screening 1 / 0 / 0 Discovery and characterization of a small molecule allosteric agonists of mas-related G-Protein coupled receptor X1 ( MrgX1)

Gene RIF (162)

26308584 culturing of reconstructed skin with microvascular endothelial cells led to increased skin pigmentation that could be prevented by inhibiting EDNRB
26240367 EDNRB plays a key role in hypoxia tolerance
26030901 The increased gene expression of MITF and EDNRB in UVB-exposed NHMs.
25946671 Endothelin receptor B expression was significantly lower while higher staining grade was found in basal cell carcinoma rather than squamous cell carcinoma or psoriasis.
25799405 Polymorphisms of the EDNRB gene may influence the susceptibility to obesity and can interact with plasma arsenic levels
25638620 Cumulative effects of the RET and EDNRB genes contribute to long-segment and total colonic aganglionosis.
25572612 Pancreatic adenocarcinoma was characterised by greater expression of ET-1 and endothelin B receptor.
25479176 The results show that MitA can effectively be used to block ETBR mediated vasoconstriction as a supplement to an existing ischemic stroke therapy.
25433721 Its expression by lymphoma and endothelial cells may mediate trafficking of tumor-infiltrated lymphocytes, which may explain the immune escape processes of primary central nervous system lymphomas.
25381251 Data show that upon endothelin-1 (ET-1) stimulation, ET type A receptor (ETAR) is recycled back to plasma membrane, whereas ET type B receptor (ETAR) is targeted to lysosome for degradation.

AA Sequence

LKFKANDHGYDNFRSSNKYSSS                                                    421 - 442

Text Mined References (195)

PMID Year Title
26308584 2015 Endothelial Cells Promote Pigmentation through Endothelin Receptor B Activation.
26240367 2015 Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice.
26030901 2015 UVB Stimulates the Expression of Endothelin B Receptor in Human Melanocytes via a Sequential Activation of the p38/MSK1/CREB/MITF Pathway Which Can Be Interrupted by a French Maritime Pine Bark Extract through a Direct Inactivation of MSK1.
25946671 2015 Immunohistochemical assessment of endothelin-1 axis in psoriasis, basal cell carcinoma and squamous cell carcinoma.
25799405 2015 Polymorphisms in endothelin system genes, arsenic levels and obesity risk.
25638620 2015 Clinical and genetic correlations of familial Hirschsprung's disease.
25572612 2015 Endothelin-1 and endothelin B receptor expression in pancreatic adenocarcinoma.
25479176 2014 Regulatory mechanism of endothelin receptor B in the cerebral arteries after focal cerebral ischemia.
25433721 2015 Perivascular microenvironment in primary central nervous system lymphomas: the role of chemokines and the endothelin B receptor.
25381251 2014 Agonist-promoted ubiquitination differentially regulates receptor trafficking of endothelin type A and type B receptors.