Tclin EDNRB Endothelin receptor type B

Protein Summary

Description

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• P24530
• A2A2Z8
• A8K3T4
• O15343
• Q59GB1
• Q5W0G9
• Q8NHM6
• Q8NHM7
• Q8NHM8
• Q8NHM9
• Q9UD23
• Q9UQK3
• ET-B

Gene Name

• EDNRB

Ensembl ID

• ENST00000334286
• ENSP00000335311
• ENSG00000136160
• ENST00000377211
• ENSP00000366416
• ENST00000475537
• ENSP00000487082
• ENST00000626030
• ENSP00000486202
• ENST00000646605
• ENSP00000494278
• ENST00000646607
• ENSP00000493527
• ENST00000646948
• ENSP00000493895

Symbol

• ETRB
• ETB
• ET-B
• ETB1
• ETBR
• ETRB
• HSCR
• WS4A
• ABCDS
• ET-BR
• HSCR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	0.94
kinase perturbation	0.93
gene perturbation	0.9
microRNA	0.84

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Endothelin Receptor / Endothelin Type B / Endothelin B Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2493.64   (req: < 5)

Gene RIFs: 194   (req: <= 3)

Antibodies: 432   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2493.64   (req: >= 5)

Gene RIFs: 194   (req: > 3)

Antibodies: 432   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 267

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4