Property Summary

NCBI Gene PubMed Count 22
Grant Count 2
Funding $60,720.2
PubMed Score 170.76
PubTator Score 82.37

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (14)

Disease log2 FC p
psoriasis -1.700 0.001
osteosarcoma 1.800 0.000
posterior fossa group A ependymoma 1.600 0.000
glioblastoma 2.100 0.000
medulloblastoma 1.900 0.000
astrocytoma 1.100 0.009
atypical teratoid / rhabdoid tumor 2.600 0.000
medulloblastoma, large-cell 2.200 0.000
primitive neuroectodermal tumor 1.500 0.000
lung cancer 1.900 0.004
pediatric high grade glioma 1.800 0.000
pilocytic astrocytoma 1.600 0.000
lung adenocarcinoma 1.022 0.001
dermatomyositis -1.100 0.001

Synonym

Accession P24390 B2R6N4 Q54A39 Q8NBW7
Symbols ERD2
HDEL
PM23
ERD2.1

Gene

 Grant Application (2)

 GO Function (1)

Gene RIF (10)

PMID Text
26861384 KDELR protein mediated the intracellular trafficking of Japanese encephalitis virus particles.
26064897 We propose a model whereby in analogy to previous findings (e.g., the RAS-RAF signalling pathway), PHB can act as a signalling scaffold protein to assist in KDELR-dependent Src activation
25682866 A Golgi-based KDELR-dependent signalling pathway controls invadopodia-dependent extracellular matrix degradation.
25117681 KDEL receptor activates CREB1 and other transcription factors that upregulate transport-related genes
23873287 It discuss the particular role of KDEL receptor signaling in the regulation of important pathways involved in the maintenance of the homeostasis of the transport apparatus, and in particular, of the Golgi complex.
22580821 These findings reveal an unexpected GPCR-like mode of action of the KDEL-R and shed light on a core molecular control mechanism of intra-Golgi traffic.
22363504 Cystinosin, MPDU1, SWEETs and KDELR belong to a well-defined protein family with putative function of cargo receptors.
21684323 our data provide evidence that KDELR, as a novel inducer of autophagy, participates in the degradation of misfolded neurodegenerative disease-related proteins.
12975382 Src relocated the KDEL receptor (KDEL-R) from the Golgi apparatus to the endoplasmic reticulum
12821650 the KDEL receptor participates in the ER stress response not only by its retrieval ability but also by modulating MAP kinase signaling

AA Sequence

MNLFRFLGDLSHLLAIILLLLKIWKSRSCAGISGKSQVLFAVVFTARYLDLFTNYISLYNTCMKVVYIAC      1 - 70
SFTTVWLIYSKFKATYDGNHDTFRVEFLVVPTAILAFLVNHDFTPLEILWTFSIYLESVAILPQLFMVSK     71 - 140
TGEAETITSHYLFALGVYRTLYLFNWIWRYHFEGFFDLIAIVAGLVQTVLYCDFFYLYITKVLKGKKLSL    141 - 210
PA                                                                        211 - 212
//

Text Mined References (26)

PMID Year Title
26861384 2016 A KDEL Retrieval System for ER-Golgi Transport of Japanese Encephalitis Viral Particles.
26064897 2015 Prohibitin: A Novel Molecular Player in KDEL Receptor Signalling.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25682866 2015 A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation.
25117681 2014 Control systems of membrane transport at the interface between the endoplasmic reticulum and the Golgi.
23873287 2013 Regulation of Golgi signaling and trafficking by the KDEL receptor.
22580821 2012 The KDEL receptor couples to G?q/11 to activate Src kinases and regulate transport through the Golgi.
22363504 2012 Cystinosin, MPDU1, SWEETs and KDELR belong to a well-defined protein family with putative function of cargo receptors involved in vesicle trafficking.
21684323 2011 The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
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