Tbio COX7A1 Cytochrome c oxidase subunit 7A1, mitochondrial

Protein Summary

Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P24310

Gene Name

• COX7A1

Ensembl ID

• ENST00000292907
• ENSP00000292907
• ENSG00000161281

Symbol

• COX7AH
• COX7A
• COX7AH
• COX7AM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
PubMedID	0.79
cellular component	0.65
transcription factor perturbation	0.61
molecular function	0.6

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Cytochrome C Oxidase Subunit 7a1, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Cytochrome C Oxidase Subunit 7a1, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.76   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 96   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.76   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0