Property Summary

NCBI Gene PubMed Count 69
PubMed Score 117.77
PubTator Score 197.33

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
psoriasis 6685 2.01984837164387E-12
tuberculosis 1563 9.30879498313508E-4
gastric cancer 436 0.00147125358348156
lung cancer 4473 0.00416745420551584
COPD 116 0.00875151600412619
mucosa-associated lymphoid tissue lymphoma 480 0.0111472193305333
non primary Sjogren syndrome sicca 840 0.0202392640086143
axial spondyloarthropathy 28 0.0435897824612634
Disease Target Count Z-score Confidence
IGA Glomerulonephritis 454 5.707 2.9
end stage renal failure 7 3.027 1.5


  Differential Expression (8)

Disease log2 FC p
gastric cancer -1.400 0.001
tuberculosis -2.300 0.001
lung cancer -1.600 0.004
non primary Sjogren syndrome sicca -1.200 0.020
COPD -1.200 0.009
mucosa-associated lymphoid tissue lympho... 2.526 0.011
axial spondyloarthropathy 1.400 0.044
psoriasis 1.100 0.000



1OVZ   1OW0   1UCT  

  Ortholog (4)

Species Source
Macaque OMA Inparanoid
Rat OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid

 CSPA Cell Line (2)

Gene RIF (44)

25907714 Findings suggest a basis for the use of Fc receptor I for IgA (FcalphaRI) as a molecular target for the treatment of lupus.
25339672 induces different forms of neutrophil death, depending on the inflammatory microenvironment
24732061 this study examined the expression of IL-4 mRNA, IFN-c mRNA and FcaRI mRNA in tonsillar mononuclear cells of IgA nephropathy9(IgAN) patients and non-IgAN patients.
21985370 These results suggest a role of anti-FcaRI Fab as a negative regulator in controlling the magnitude of the innate immune response
21866091 Abnormally glycosylated IgA1 and soluble CD89-IgA and IgA-IgG complexes, features of primary IgA nephropathy, are also present in alcoholic cirrhosis.
21784854 Glycosylation of the CH2/CH3 interface inhibits interaction with the pathogen IgA binding protein SSL7, while maintaining binding of pIgR, essential to the biosynthesis and transport of SIgA.
21750160 FCAR polymorphism is not associated with high susceptibility to IGA nephropathy in caucasians.
21653835 In this study, human mammary carcinoma cells are efficiently killed when incubated with human neutrophils and tumor-specific FcalphaRI bispecific or immunoglobulin A antibodies.
21383176 FcalphaRI defines a function for pentraxins in inflammatory responses involving neutrophils and macrophages. It also highlights the innate aspect of otherwise humoral immunity-associated antibody receptors.
21273231 Genetic variation at the promoter region of IgA receptor is associated with IgA nephropathy.

AA Sequence

RTPSVCK                                                                   281 - 287

Text Mined References (70)

PMID Year Title
25907714 2015 Targeted IgA Fc receptor I (Fc?RI) therapy in the early intervention and treatment of pristane-induced lupus nephritis in mice.
25339672 2014 Human IgA Fc receptor Fc?RI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment.
24732061 Expression and correlation analysis of IL-4, IFN-? and Fc?RI in tonsillar mononuclear cells in patients with IgA nephropathy.
21985370 2011 Negative regulation of inflammatory responses by immunoglobulin A receptor (Fc?RI) inhibits the development of Toll-like receptor-9 signalling-accelerated glomerulonephritis.
21866091 2011 Both IgA nephropathy and alcoholic cirrhosis feature abnormally glycosylated IgA1 and soluble CD89-IgA and IgG-IgA complexes: common mechanisms for distinct diseases.
21784854 2011 Interaction of human, rat, and mouse immunoglobulin A (IgA) with Staphylococcal superantigen-like 7 (SSL7) decoy protein and leukocyte IgA receptor.
21750160 2012 Single nucleotidic polymorphism 844 A->G of FCAR is not associated with IgA nephropathy in Caucasians.
21653835 2011 Targeting Fc?RI on polymorphonuclear cells induces tumor cell killing through autophagy.
21383176 2011 Recognition and functional activation of the human IgA receptor (FcalphaRI) by C-reactive protein.
21273231 2011 Association of -27T>C and its haplotype at the putative promoter for IgA-specific receptor gene with IgA nephropathy among the Chinese Han population.