Protein Summary
Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- ENST00000008180
- ENSP00000008180
- ENSG00000008517
- ENST00000325568
- ENSP00000324742
- ENST00000382213
- ENSP00000371648
- ENST00000396887
- ENSP00000380096
- ENST00000396890
- ENSP00000380099
- ENST00000440815
- ENSP00000405063
- ENST00000444393
- ENSP00000411958
- ENST00000525643
- ENSP00000432218
- ENST00000526464
- ENSP00000450364
- ENST00000528163
- ENSP00000432850
- ENST00000529550
- ENSP00000437020
- ENST00000530538
- ENSP00000436929
- ENST00000530890
- ENSP00000433747
- ENST00000531965
- ENSP00000433177
- ENST00000533097
- ENSP00000432917
- ENST00000534507
- ENSP00000431775
- ENST00000548246
- ENSP00000447979
- ENST00000548476
- ENSP00000449483
- ENST00000548652
- ENSP00000446624
- ENST00000549213
- ENSP00000447812
- ENST00000551122
- ENSP00000447496
- ENST00000552356
- ENSP00000446978
- ENST00000552664
- ENSP00000448683
- NK4
- TAIF
- NK4
- TAIF
- TAIFa
- TAIFb
- TAIFc
- TAIFd
- IL-32beta
- IL-32alpha
- IL-32delta
- IL-32gamma
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.83 | ||
small molecule perturbation | 0.59 | ||
gene perturbation | 0.57 | ||
PubMedID | 0.53 | ||
tissue sample | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 431.97 (req: < 5)
Gene RIFs: 218 (req: <= 3)
Antibodies: 546 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 431.97 (req: >= 5)
Gene RIFs: 218 (req: > 3)
Antibodies: 546 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0