Property Summary

NCBI Gene PubMed Count 77
PubMed Score 102.72
PubTator Score 81.99

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Lung Neoplasms 171
Disease Target Count P-value
malignant mesothelioma 3163 4.49511834609579E-7
atypical teratoid / rhabdoid tumor 4369 3.24873340142001E-6
pilocytic astrocytoma 3086 6.54367587950172E-6
glioblastoma 5572 3.28673483878649E-5
cystic fibrosis 1670 4.32787412215333E-5
ductal carcinoma in situ 1745 9.73349618014899E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 1.95991994728208E-4
medulloblastoma, large-cell 6234 4.42085585029165E-4
colon cancer 1475 9.00879411976707E-4
psoriasis 6685 9.39374311475298E-4
adult high grade glioma 2148 0.00142645125809087
osteosarcoma 7933 0.00230517615774051
medulloblastoma 1524 0.00332221863542407
lung cancer 4473 0.00650845588703553
invasive ductal carcinoma 2950 0.00822926241460268
active ulcerative colitis 477 0.00885764132974587
urothelial carcinoma 318 0.0235437296148704
Disease Target Count Z-score Confidence
Cancer 2346 3.148 1.6


  Differential Expression (17)

Disease log2 FC p
urothelial carcinoma 1.200 0.024
malignant mesothelioma 1.500 0.000
psoriasis -1.200 0.001
osteosarcoma 1.745 0.002
atypical teratoid / rhabdoid tumor 1.500 0.000
glioblastoma 1.500 0.000
medulloblastoma 1.500 0.003
medulloblastoma, large-cell 1.600 0.000
intraductal papillary-mucinous adenoma (... 1.200 0.000
lung cancer 1.500 0.007
colon cancer 1.400 0.001
active ulcerative colitis -1.347 0.009
cystic fibrosis -1.300 0.000
adult high grade glioma -1.200 0.001
pilocytic astrocytoma -1.300 0.000
ductal carcinoma in situ 1.300 0.000
invasive ductal carcinoma 1.300 0.008


Accession P23511 Q8IXU0
Symbols HAP2


PANTHER Protein Class (1)



  Ortholog (14)

Gene RIF (47)

26921500 our results indicate that NF-YA alternative splicing is an influential muscle cell determinant, through direct regulation of selected cell cycle blocking genes, and, directly and indirectly, of muscle-specific transcription factors
26732297 A direct non-transcriptional role of NF-Y in the overall efficiency of DNA replication, specifically in the DNA elongation process.
26509926 Presence of NF-Y transcription factor plays a pivotal role in transcriptional regulation of ID genes in development.
26170459 enhanced CDCA8 promoter activities by NF-Y overexpression and reduced CDCA8 transcription by NF-Y knockdown further verified that NF-Y is a positive regulator of CDCA8 transcription.
25756534 NF-Y inhibits NT2/D1 cell growth in p53-independent manner and decreases SOX2 expression.
25473899 Data show that Zinc-fingers and homeoboxes 2 (ZHX2) represses nuclear transcription factor Y alpha (NF-Y)-mediated activation of multidrug resistance 1 (MDR1) transcription.
25463392 Stimulation of the lymphocytes with phytohemagglutinin, restores normal OGG1 levels and repair rates. MAP kinase c-Jun N-terminal kinase (JNK) and the recruitment of the transcription factor NFYA to the promoter region of OGG1 are shown to be involved.
24407240 Association of p21 with NF-YA suppresses the expression of PLK1 and prevents mitotic death in response to DNA damage.
23595228 NF-YA binds directly over the CCAAT sequence.
23332751 The crystal structure of NF-Y bound to a 25 bp CCAAT oligonucleotide shows that the histone-fold domains dimer binds to the DNA sugar-phosphate backbone, mimicking the nucleosome H2A/H2B-DNA assembly; NF-YA both binds to NF-YB/NF-YC and inserts an alpha helix deeply into the DNA minor groove, providing sequence-specific contacts to the CCAAT box.

AA Sequence


Text Mined References (80)

PMID Year Title
26921500 2016 NF-YA splice variants have different roles on muscle differentiation.
26732297 2016 Direct non transcriptional role of NF-Y in DNA replication.
26509926 2015 Epigenetic role of CCAAT box-binding transcription factor NF-Y on ID gene family in human embryonic carcinoma cells.
26170459 2015 Transcriptional activation of human CDCA8 gene regulated by transcription factor NF-Y in embryonic stem cells and cancer cells.
25756534 2015 Transcription factor NF-Y inhibits cell growth and decreases SOX2 expression in human embryonal carcinoma cell line NT2/D1.
25473899 2015 ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF-YA.
25463392 2015 The repair of oxidized purines in the DNA of human lymphocytes requires an activation involving NF-YA-mediated upregulation of OGG1.
25416956 2014 A proteome-scale map of the human interactome network.
24407240 2014 Association of p21 with NF-YA suppresses the expression of Polo-like kinase 1 and prevents mitotic death in response to DNA damage.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.