JAK1
Tyrosine-protein kinase JAK1
Protein Summary
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529). This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
- ENST00000342505
- ENSP00000343204
- ENSG00000162434
- JAK1A
- JAK1B
- JTK3
- JAK1A
- JAK1B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
hub protein | 1 | ||
protein domain | 1 | ||
virus perturbation | 1 | ||
molecular function | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1227.42 (req: < 5)
Gene RIFs: 222 (req: <= 3)
Antibodies: 565 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1227.42 (req: >= 5)
Gene RIFs: 222 (req: > 3)
Antibodies: 565 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3110
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 12