Property Summary

NCBI Gene PubMed Count 17
Grant Count 2
Funding $68,722.6
PubMed Score 10.75
PubTator Score 21.32

Knowledge Summary

Patent (5,725)

Expression

  Differential Expression (3)

Disease log2 FC p
medulloblastoma 1.100 0.024
medulloblastoma, large-cell 1.400 0.000
psoriasis -1.200 0.007

Gene RIF (6)

PMID Text
22606311 investigated neural progenitor cells in respect to their glycine receptor function and subunit expression using electrophysiology, calcium imaging, immunocytochemistry, and quantitative real-time PCR
20237295 Enhancement of azurophil granule-phagosome fusion via glycine receptor alpha 2 subunit (GlyRalpha2)/transient receptor potential melastatin (TRPM)2/p38 MAP kinase signaling is a novel target for enhancement of neutrophil bactericidal activity.
19874574 Observational study of gene-disease association. (HuGE Navigator)
19086053 Observational study of gene-disease association. (HuGE Navigator)
16144831 The molecular basis for the differential sensitivity of GlyR alpha(1) and GlyR alpha(2) to Zn(2+) potentiation is reported.
15147510 Effects of 12 times normal atmospheric pressure of helium-oxygen gas (pressure) on ethanol-induced potentiation of GlyR function in Xenopus oocytes expressing human alpha1, alpha2 or the mutant alpha1(A52S) GlyRs were measured by voltage clamp technics

AA Sequence

MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPP      1 - 70
VNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGA     71 - 140
NFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPV    141 - 210
QVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINM    211 - 280
DAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLR    281 - 350
LRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDT    351 - 420
ISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK                                          421 - 452
//

Text Mined References (20)

PMID Year Title
25445488 2015 Functional reconstitution of glycinergic synapses incorporating defined glycine receptor subunit combinations.
23895467 2013 Zinc-dependent modulation of ?2- and ?3-glycine receptor subunits by ethanol.
22606311 2012 Differentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing ?2? subunits.
20237295 2010 Lysophosphatidylcholine increases neutrophil bactericidal activity by enhancement of azurophil granule-phagosome fusion via glycine.GlyR alpha 2/TRPM2/p38 MAPK signaling.
19874574 2009 Genetical genomic determinants of alcohol consumption in rats and humans.
19086053 2009 Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16144831 2005 Molecular basis for zinc potentiation at strychnine-sensitive glycine receptors.
15772651 2005 The DNA sequence of the human X chromosome.
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