Tclin GLRA1 Glycine receptor subunit alpha-1

Protein Summary

Description

Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• P23415
• B2R6T3
• Q14C77
• Q6DJV9

Gene Name

• GLRA1

Ensembl ID

• ENST00000274576
• ENSP00000274576
• ENSG00000145888
• ENST00000455880
• ENSP00000411593

Symbol

• STHE
• HKPX1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
protein domain	0.92
biological term	0.82
biological process	0.75
ligand (chemical)	0.74

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Acetylcholine Receptor / Glycine Receptor Subunit Alpha-1

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Gaba Receptor / Glycine Receptor Subunit Alpha-1

Protein / Receptor / Ligand-gated Ion Channel / Acetylcholine Receptor / Glycine Receptor Subunit Alpha-1

Protein / Receptor / Ligand-gated Ion Channel / Gaba Receptor / Glycine Receptor Subunit Alpha-1

DTO Classes

Protein / Ion Channel / Neurotransmitter Receptor, Cys Loop, Ligand-gated Ion Channel (Lic) Family / Glycine Receptor Subfamily / Glra1 Sub-subfamily / Glycine Receptor Subunit Alpha-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.48   (req: < 5)

Gene RIFs: 98   (req: <= 3)

Antibodies: 379   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 202.48   (req: >= 5)

Gene RIFs: 98   (req: > 3)

Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 76

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 20