Tchem PPIB Peptidyl-prolyl cis-trans isomerase B

Protein Summary

Description

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P23284
• A8K534
• Q6IBH5
• Q9BVK5
• PPIase B

Gene Name

• PPIB

Ensembl ID

• ENST00000300026
• ENSP00000300026
• ENSG00000166794

Symbol

• CYPB
• B
• OI9
• CYPB
• SCYLP
• CYP-S1
• HEL-S-39

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.97
disease perturbation	0.96
cellular component	0.86
kinase perturbation	0.84
transcription factor perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.73   (req: < 5)

Gene RIFs: 49   (req: <= 3)

Antibodies: 449   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.73   (req: >= 5)

Gene RIFs: 49   (req: > 3)

Antibodies: 449   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1