Property Summary

NCBI Gene PubMed Count 70
Grant Count 73
R01 Count 49
Funding $8,505,974.64
PubMed Score 369.54
PubTator Score 136.66

Knowledge Summary

Patent

No data available

Expression

Synonym

Accession P22897 A5PKW3 Q5VSJ2 Q5VSK2 MMR
Symbols MMR
hMR
CD206
MRC1L1
CLEC13D
CLEC13DL
bA541I19.1

Gene

PANTHER Protein Class (1)

PDB

1EGG   1EGI  

Gene RIF (71)

PMID Text
26352004 Findings show that CD206 was highly expressed in the hepatocellular carcinoma (HCC) tissues and indicate that CD206 is a potential biomarker for predicting HCC prognosis.
26209923 Data show that umbilical cord-derived mesenchymal stem cells (UCMSCs) transplantation promoted the expression of CD206 antigen and increased phagocytic activity of macrophages through interleukin-6 (IL-6) in systemic lupus erythematosus (SLE) patients.
26202986 Data indicate that mannose receptor (CD206) is a major binding receptor for gamma-tilmanocept.
26169445 CD206 is a novel biomarker of alternative macrophage activation and treatment outcome in multiple myeloma.
25614715 CD206+ cells differentiate between influenza A (H1N1)pdm09 and seasonal influenza virus in lung tissue of fatal cases
25182001 TAMs phenotypes of glioma samples are the potential biomarkers in assessing the degree of malignancy, tumor invasion, and patient prognosis in clinic.
25146376 Increased expression of CD206 was found in perivascular macrophages from HIV-infected brain.
25057126 The genome wide significant association of MRC1 with sCOMP levels was found likely to act independent of osteoarthritis subtypes.
24969847 MRC-1 SNP, rs691005 was found to be associated with sustained viral response in HCV-1-infected patients; identified an interaction between MRC-1 rs691005 and IL-28B rs8099917 and response
24498098 There was a significant negative correlation between the number of CD163(+), CD204(+) or CD206(+) alveolar macrophages.
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AA Sequence

MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRWVSESQIMSVA      1 - 70
FKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYGNRQEKNIMLYKGSGLWSRWK     71 - 140
IYGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCP    141 - 210
LKFEGSESLWNKDPLTSVSYQINSKSALTWHQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIG    211 - 280
LNSLSFNSGWQWSDRSPFRYLNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSF    281 - 350
VIPSESDVPTHCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPND    351 - 420
ELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEWPLGYICKMKS    421 - 490
RSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLTTIEDRYEQAFLTSFVGLRPE    491 - 560
KYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGCVAMRTGIAGGLWDVLKCDEKAKFVCKHWAE    561 - 630
GVTHPPKPTTTPEPKCPEDWGASSRTSLCFKLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIW    631 - 700
RLITASGSYHKLFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCE    701 - 770
HLNNWICQIQKGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQS    771 - 840
ESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCVTMYSNSGFWN    841 - 910
DINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIFGFMEEERKNWQEARKACIGF    911 - 980
GGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDA    981 - 1050
DCVVIIGGASNEAGKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAE   1051 - 1120
TYCKLHNSLIASILDPYSNAFAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSAC   1121 - 1190
VYLDLDGYWKTAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQAS   1191 - 1260
LECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNWNTGDPSGERN   1261 - 1330
DCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRKMDPSKPSSNVAGVVIIVILLIL   1331 - 1400
TGAGLAAYFFYKKRRVHLPQEGAFENTLYFNSQSSPGTSDMKDLVGNIEQNEHSVI                 1401 - 1456
//

Text Mined References (75)

PMID Year Title
26352004 2015 GdCl3 suppresses the malignant potential of hepatocellular carcinoma by inhibiting the expression of CD206 in tumor?associated macrophages.
26209923 2015 Mesenchymal stem cells promote CD206 expression and phagocytic activity of macrophages through IL-6 in systemic lupus erythematosus.
26202986 2015 ?-Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206).
26169445 2015 The novel biomarker of alternative macrophage activation, soluble mannose receptor (sMR/sCD206): Implications in multiple myeloma.
25614715 2014 CD206+ cell number differentiates influenza A (H1N1)pdm09 from seasonal influenza A virus in fatal cases.
25182001 2014 Expression of tumor-associated macrophage in progression of human glioma.
25146376 2014 Expression of the mannose receptor CD206 in HIV and SIV encephalitis: a phenotypic switch of brain perivascular macrophages with virus infection.
25057126 2014 Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance.
24969847 2014 Association of MRC-1 and IL-28B with the treatment outcome of hepatitis C: a case control study.
24498098 2014 Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease.
More...