Property Summary

NCBI Gene PubMed Count 80
PubMed Score 283.67
PubTator Score 210.57

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
lung carcinoma 2844 9.87668105699229E-13
Duchenne muscular dystrophy 602 1.36865544373132E-9
chronic lymphosyte leukemia 232 4.53186496291258E-9
ovarian cancer 8492 3.20891327561503E-8
juvenile dermatomyositis 1189 1.40832931162678E-7
malignant mesothelioma 3163 4.44543774429421E-7
glioblastoma 5572 6.78264028319577E-6
psoriasis 6685 1.37773513779896E-5
pediatric high grade glioma 2712 3.15907251797787E-5
pituitary cancer 1972 3.43006702523351E-5
posterior fossa group A ependymoma 1511 1.22786975061301E-4
atypical teratoid / rhabdoid tumor 4369 2.38165808498144E-4
limb girdle muscular dystrophy 2B 74 4.90162018963366E-4
Becker muscular dystrophy 187 0.00116716138698681
medulloblastoma 1524 0.00119073424374954
adrenocortical carcinoma 1427 0.00127794748703096
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00222401649101834
interstitial cystitis 2299 0.00257098175923986
acute quadriplegic myopathy 1157 0.00267033726372344
primary pancreatic ductal adenocarcinoma 1271 0.00301142007093424
pancreatic cancer 2300 0.00350055344974906
interstitial lung disease 292 0.00452064576677276
pilocytic astrocytoma 3086 0.00654117538801756
cystic fibrosis 1670 0.00656844449249772
medulloblastoma, large-cell 6234 0.0108888335993828
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0120945948004143
gastric carcinoma 832 0.0122851787751672
primitive neuroectodermal tumor 3031 0.0180686103872439
mucosa-associated lymphoid tissue lymphoma 480 0.0262364083883014
active Crohn's disease 918 0.0350499846421667
diabetes mellitus 1663 0.0470074890661646
Disease Target Count Z-score Confidence
Acquired metabolic disease 267 0.0 2.0
Disease Target Count Z-score Confidence
Cancer 2346 3.575 1.8



Accession P22692 A0N9W2 B4E351 Q5U012 Q9UCL6 IBP-4
Symbols BP-4



1WQJ   2DSP   2DSQ   2DSR  

  Ortholog (12)

Gene RIF (47)

27019456 Data show that insulin-like growth factor binding protein-4 (IGFBP-4) was significantly elevated in lupus nephritis, particularly those with renal pathology chronicity changes.
26195635 Data show that co-transfection with cDNA encoding stanniocalcin-1 abrogates the proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) toward IGF-binding protein 4 (IGFBP-4).
26135353 The present study provides the first evidence that apoptosis inhibitor of macrophages binds to IGFBP2, 3 and 4.
26046968 High IGFBP-4 fragment levels were associated with increased all-cause and cardiovascular mortality rates in T1D patients with and without diabetic nephropathy.
25489725 PLasma IGFBP-4 levels are not acutely altered following myocardial infarction treated with heparin and percutaneous coronary intervention.
25475528 Data indicate co-localization of insulin-like growth factor binding proteins IGFBP-4, IGFBP-5 in the syncytiotrophoblast layer of first trimester placental villi as early as 5 weeks of gestational age.
24778188 IGF-1/IGFbp4 signaling regulated the post-developmental adipose tissue expansion.
24201068 Despite the relation of CT-IGFBP4 to a more severe coronary artery disease, CT- and NT-IGFBP4, in contrast to our report based on total PAPP-A, failed to predict any long-term outcomes in patients with stable cardiovascular disease.
24060054 PAPP-A and IGFBP-4 gene expression (microarray analysis) was significantly upregulated in IL-1beta- or TNF-alpha-exposed cells.
23975422 these findings demonstrate an oncogenic property for IBP in promoting the metastatic potential of breast cancer cells.

AA Sequence


Text Mined References (87)

PMID Year Title
27019456 2016 Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis.
26195635 2015 Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A.
26135353 2015 Interaction of AIM with insulin-like growth factor-binding protein-4.
26091039 2015 A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
26046968 2015 IGFBP-4 Fragments as Markers of Cardiovascular Mortality in Type 1 Diabetes Patients With and Without Nephropathy.
25489725 2015 PAPP-A and IGFBP-4 fragment levels in patients with ST-elevation myocardial infarction treated with heparin and PCI.
25475528 2014 IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells.
24778188 2014 Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.
24431302 2014 Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.